Large-Scale Cyclopropanation of Butyl Acrylate with Difluorocarbene and Classical Resolution of a Key Fluorinated Building Block

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Attrition-enhanced total resolution leads to homochiral families of amino acid derivatives

Publication
Tetrahedron: Asymmetry, 2010, 21, 1191
Year
2010
Customer
DSM
Symeres authors
Michel Leeman, Jesse de Gooijer, Karin Boer, Karen Zwaagstra, Richard Kellogg
Publication

A facile synthesis of 2,3-azaisoindoline

Publication
Tetrahedron Letters 51 (2010) 5859-5860
Year
2010
Customer
Pfizer
Symeres authors
Michel van den Berg, Kees Pouwer
Publication

Quantification of the Emetic Toxin Cereulide in Food Products by Liquid Chromatography-Mass Spectrometry Using Synthetic Cereulide as a Standard

Publication
Appl. Env. Microbiol. (2010), 76(22), 7466-7472
Year
2010
Customer
Chiralix
Symeres authors
Richard Blaauw
Publication

The Resolution of 2-Hydroxy-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphorinan 2-Oxide (Phencyphos) by Preferential Crystallization

Publication
Organic Process Research & Development 2009, 13, 1379
Year
2009
Customer
DSM
Symeres authors
Michel Leeman, Ton Vries, Richard Kellogg
Publication

Nucleation Inhibition in Attrition-Enhanced Pope-Peachey Type of Diastereomeric Resolutions

Publication
Tetrahedron: Asymmetry, 2009, 20, 1363
Year
2009
Customer
DSM
Symeres authors
Michel Leeman, Richard Kellogg
Publication

From Ostwald Ripening to Single Chirality

Publication
Angew. Chem. Int. Ed., 2009, 48, 9600-9606
Year
2009
Customer
DSM
Symeres authors
Richard Kellogg
Publication

Fast Attrition-Induced Deracemization of Naproxen by a Gradual in situ Feed

Publication
Angew. Chem. Int. Ed., 2009, 48, 4581
Year
2009
Customer
DSM
Symeres authors
xxx
Publication

Downstream processing of human antibodies integrating an extraction capture step and cation exchange chromatography.

Publication
J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jan 1;877(1-2):50-8
Year
2009
Customer
IBB-Institute for Biotechnology and Bioengineering
Symeres authors
xxx
Publication

Complete Chiral Symmetry Breaking of an Amino Acid Derivative Directed by Circularly Polarized Light

Publication
Nature Chemistry, 2009, 1, 729-732
Year
2009
Customer
Radboud University Nijmegen
Symeres authors
xxx
Publication

Complete Chiral Resolution Using Additive-Induced Crystal Size Bifurcation During Grinding

Publication
Angew. Chem. Int. Ed., 2009, 48, 3278
Year
2009
Customer
Radboud University Nijmegen
Symeres authors
Michel Leeman, Richard Kellogg
 
 

Development Centres of Excellence Network Lead Optimization Hit Generation Lead Optimization
 
 
 
 
 

Development Centres of Excellence Network Lead Optimization Hit Generation Lead Optimization
 
 
 
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