Large-Scale Cyclopropanation of Butyl Acrylate with Difluorocarbene and Classical Resolution of a Key Fluorinated Building Block

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Publication

Attrition-Enhanced Deracemization in the Synthesis of Clopidogrel; A Practical Application of a New Discovery

Publication
Organic Process Research & Development 2009, 13,1195
Year
2009
Customer
Radboud University Nijmegen
Symeres authors
Maarten van der Meijden, Michel Leeman, Edith Gelens, Richard Kellogg
Publication

Synthesis of tert-Butyl 6-Oxo-2-azaspiro[3.3]heptane-2-carboxylate

Publication
Org. Lett., 2009, 11 (16), pp 3523–3525
Year
2009
Customer
Pfizer
Symeres authors
Inouk Muizebelt, Jim van Wiltenburg
Publication

Affinity-enhanced purification of human antibodies by aqueous two-phase extraction.

Publication
Separation and Purification Technology, 65 (1), p.31-39, Feb 2009
Year
2009
Customer
IBB, Institute for Biotechnology and Bioengineering
Symeres authors
Jelle de Vries, Ronald Korporaal, Ton Visser
Publication

Epiquinamide: A Poison That Wasn’t from a Frog That Was

Publication
J. Nat. Prod. (2009), 72(2), 243-247
Year
2009
Customer
Chiralix
Symeres authors
Richard Blaauw
Publication

Complementary chemoenzymatic routes to both enantiomers of febrifugine

Publication
Org. Biomol. Chem. (2009), 7(14), 2976-2980
Year
2009
Customer
Chiralix
Symeres authors
Richard Blaauw
Publication

Complete Deracemization by Attrition-Enhanced Ostwald Ripening Elucidated

Publication
Angew. Chem. Int. Ed., 2008, 47, 6445-6447
Year
2008
Customer
DSM
Symeres authors
Michel Leeman, Richard Kellogg
Publication

The Thulium Complex of 1,4,7,10-Tetrakis{[N-(1H-imidazol-2-yl)carbamoyl]methyl}-1,4,7,10-tetraazacyclododecane (dotami) as a ParaCEST Contrast Agent

Publication
Chemistry & Biodiversity 2008, 5, 8, 1505-1512
Year
2008
Customer
TU Eindhoven
Symeres authors
Wolter ten Hoeve
Publication

Structural Aspects of Nucleation Inhibitors for Diastereomeric Resolutions and the Relationship to Dutch Resolution

Publication
Angew. Chem. Int. Ed., 2008, 1287-1290
Year
2008
Customer
DSM
Symeres authors
Michel Leeman, Elly Smits, Jim van Wiltenburg
Publication

Large-Scale Synthesis of the Glucosylceramide Synthase Inhibitor N-[5-(Adamantan-1-yl-methoxy)-pentyl]-1-deoxynojirimycin

Publication
Org. Process Res. Dev. 2008, 12, 414
Year
2008
Customer
Symeres authors
Publication

Explanation for the Emergence of a Single Chiral Solid State During Attrition-Enhanced Ostwald Ripening: Survival of the Fittest

Publication
Cryst. Growth Des., 2008, 8, 1675-1681
Year
2008
Customer
Radboud University Nijmegen
Symeres authors
Richard Kellogg
 
 

Development Centres of Excellence Network Lead Optimization Hit Generation Lead Optimization
 
 
 
 
 

Development Centres of Excellence Network Lead Optimization Hit Generation Lead Optimization
 
 
 
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