Large-Scale Cyclopropanation of Butyl Acrylate with Difluorocarbene and Classical Resolution of a Key Fluorinated Building Block

Publication

Modular Medical Imaging Agents Based on Azide–Alkyne Huisgen Cycloadditions: Synthesis and Pre-Clinical Evaluation of 18F-Labeled PSMA-Tracers for Prostate Cancer Imaging

Publication
Chemistry A European Journal 27, 23, 6993
Year
2020
Customer
Dutch Provinces Overijssel and Gelderland
Symeres authors
Marten Klopstra, Ton Visser, Keimpe-Oeds van den Berg
Publication

Methylation of geometrically constrained lysine analogues by histone lysine methyltransferases

Publication
Chem. Commun. (2020), 56(20), 3039-3042
Year
2020
Customer
Chiralix
Symeres authors
Richard Blaauw
Publication

Bivalent Ligands for Protein Degradation in Drug Discovery

Publication
Comp. and Struc. Biotech. J., (17), 2019, 160-176
Year
2019
Customer
MercachemSyncom
Symeres authors
Marcel Scheepstra, Koen Hekking, Luc van Hijfte, Rutger Folmer
Publication

Novel SAR for quinazoline inhibitors of EHMT1 and EHMT2

Publication
Bioorganic & Medicinal Chemistry Letters, 2019, (17), 2516-2524
Year
2019
Customer
Eurostar grant, with Proqinase
Symeres authors
Ruben Leenders, Remco Zijlmans, Bart van Bree, Marc van de Sande, FedericaTrivarellia, Eddy Damen, Anita Wegert, Gerhard Müller
Publication

Fast Iterative Synthetic Approach toward Identification of Novel Highly Selective p38 MAP Kinase Inhibitors

Publication
J. Med. Chem, 2019 (62), 10757-10782
Year
2019
Customer
Goethe University Frankfurt
Symeres authors
Rob Winkel, Koen Hekking, Jorg Benningshof
Publication

A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam

Publication
Organic & Biomolecular Chemistry, 2019, 17, 35-38
Year
2019
Customer
AMOLF
Symeres authors
Michel Leeman, Richard Kellogg,
Publication

A chiral switch: balancing between equilibrium and non-equilibrium states

Publication
Chem. Comm, 2019, in press
Year
2019
Customer
AMOLF
Symeres authors
Michel Leeman, Richard Kellogg
Publication

Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation

Publication
Drug Design, Development and Therapy 2019, 13, 345-364
Year
2019
Customer
VU UMC, UMCG, Chaperone Pharma
Symeres authors
Jean-Paul Seerden, Lizette Loen, Andre Heeres
Publication

Stable pantothenamide bioisosteres: novel antibiotics for Gram-positive bacteria

Publication
J. Antibiotics (2019), 72, 682-692
Year
2019
Customer
Chiralix
Symeres authors
Richard Blaauw
Publication

Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum

Publication
Sci. Transl. Med. (2019), 11(510), eaas9917
Year
2019
Customer
Chiralix
Symeres authors
Richard Blaauw
 
 

Development Centres of Excellence Network Lead Optimization Hit Generation Lead Optimization
 
 
 
 
 

Development Centres of Excellence Network Lead Optimization Hit Generation Lead Optimization
 
 
 
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