Large-Scale Cyclopropanation of Butyl Acrylate with Difluorocarbene and Classical Resolution of a Key Fluorinated Building Block

Publication

Structure–Activity Relationship Studies on (R)-PFI-2 Analogues as Inhibitors of Histone Lysine Methyltransferase SETD7

Publication
ChemMedChem, 2018, 13, 1405 – 1413
Year
2018
Customer
Institute for Molecules and Materials
Symeres authors
Eddy Damen, Ruben Leenders, Richard Blaauw
Publication

Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity

Publication
Journal of Medicinal Chemistry, 2018, 61, (9), 3870-3888
Year
2018
Customer
TI Pharma
Symeres authors
Johan Veerman, Toine van de Bergh
Publication

Microwave-assisted diastereoselective two-step three-component synthesis for rapid access to drug-like libraries of substituted 3-amino-β-lactams

Publication
Bioorg. Med. Chem. 2018, 26, 41-49
Year
2018
Customer
Leiden University Medical Center
Symeres authors
Joyce van den Heuvel, Rik Megens, Jorg Benningshof
Publication

The Strecker reaction coupled to Viedma ripening: a simple route to highly hindered enantiomerically pure amino acids

Publication
Chem. Comm., 2018, 54, 10832-10834
Year
2018
Customer
AMOLF
Symeres authors
Michel Leeman, Richard Kellogg
Publication

Synthesis of yellow fluorescent dyes derived from benzoxanthene that can be used in colour converters for remote phosphor LED systems

Publication
Dyes and pigments, 2018, 149, 662-668
Year
2018
Customer
Philips
Symeres authors
Sylvain Hamon, Ton Visser
Publication

Drug-target residence time: A misleading concept

Publication
Drug Discovery 23, 1, (2018,) 12-16
Year
2018
Customer
Symeres authors
Rutger folmer
Publication

A multi-gram-scale stereoselective synthesis of Z-endoxifen

Publication
Bioorg. Med. Chem. Lett 28 (2018) 1352–1356
Year
2018
Customer
TU eindhoven
Symeres authors
Bartjan Koning, Jan Koek
Publication

Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors

Publication
J. Med. Chem. 2017, 60 (17), 7371-7392
Year
2017
Customer
Galapagos
Symeres authors
Jörg Heiermann, Willem Hengelveld, Gregor Pilzak
Publication

Design and Synthesis of Enantiomerically Pure Decahydroquinoxalines as Potent and Selective k-Opioid Receptor Agonists with Anti-Inflammatory Activity in Vivo

Publication
J. Med. Chem. 2017, 60 (6), 2526-2551
Year
2017
Customer
Dr. August Wolff
Symeres authors
Peter Molenveld, Roy Storcken, Renaud Bouzanne des Mazery, Geert-Jan Sterk, Reshma Autar, Marjon Bolster, Clemens Wagner, Frank van Holst, Anita Wegert
Publication

Charting Biologically Relevant Spirocyclic Compound Space

Publication
Chem. Eur. J. 2017, 23 (3), 703-710
Year
2017
Customer
ELF
Symeres authors
Gerhard Müller, Tim Berkenbosch, Jorg Benningshof
 
 

Development Centres of Excellence Network Lead Optimization Hit Generation Lead Optimization
 
 
 
 
 

Development Centres of Excellence Network Lead Optimization Hit Generation Lead Optimization
 
 
 
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