Large-Scale Cyclopropanation of Butyl Acrylate with Difluorocarbene and Classical Resolution of a Key Fluorinated Building Block

Publication

Synthesis and Properties of 2-Oxa-6-azaspiro[3.3]heptane Sulfonate Salts

Publication
Synthesis 2017, 49 (11), 2394-2401
Year
2017
Customer
Bayer Pharma
Symeres authors
Richard van der Haas, Jeroen Dekker, Eric Damen
Publication

Piperidine and octahydropyrano[3,4-c] pyridine scaffolds for drug-like molecular libraries of the European Lead Factory

Publication
Bioorg. Med. Chem. 2017, 5160 - 5170
Year
2017
Customer
Leiden Institute of Chemistry
Symeres authors
Dirk Vandenput, Joeri Scheidt, Jorg Benningshof
Publication

Synthesis and evaluation of analogs of the phenylpyridazinone NPD-001 as potent trypanosomal TbrPDEB1 phosphodiesterase inhibitors and in vitro trypanocidal

Publication
Bioorg. Med. Chem. 2016, 24 (7), 1573-1581
Year
2016
Customer
VU
Symeres authors
Johan Veerman, Toine van den Bergh, Geert-Jan Sterk
Publication

Securing Important Strigolactone Key Structures: Orobanchol and 5-Deoxystrigol

Publication
Eur. J. Org. Chem. 2016 (12), 2163–2169
Year
2016
Customer
Radboud University
Symeres authors
Colinda van Tilburg‐Joukema, Bram van Oss, Peter Molenveld
Publication

Strategic and tactical approaches to the synthesis of 5,6-dihydro-[1,2,4]oxadiazines

Publication
Heterocycles 2016, 92 (12), 2166-2200.
Year
2016
Customer
Mercachem
Symeres authors
Johan Veerman, Yorik Bruseker, Bart van Esseveldt, Erik Heijne, Tommi Meulemans, Peter van Rijnsbergen, Wim Zonneveld
Publication

Synthesis, Properties, and Two-Dimensional Adsorption Characteristics of 5-Amino[6]hexahelicene

Publication
Chemistry, A European Journal 2016, 22, 4, 1484–1492
Year
2016
Customer
Symeres authors
Maarten van der Meijden, Edith Gelens, Richard Kellogg
Publication

Efficient reagent-saving method for the N-terminal labeling of bioactive peptides with organometallic carboxylic acids by solid-phase synthesis

Publication
Organometallics (2016), 35(18), 3192-3196
Year
2016
Customer
Wageningen University
Symeres authors
Jack Slootweg
Publication

Expansion of chemical space for collaborative lead generation and drug discovery: the European Lead Factory Perspective

Publication
Drug Disc. Today 2015, 20 (11), 1310-1316
Year
2015
Customer
Taros Chemicals
Symeres authors
Jorg Benningshof, Kees Pouwer, Gerhard Müller
Publication

Conformationally restricted k-opioid receptor agonists: Synthesis and pharmacological evaluation of diastereoisomeric and enantiomeric decahydroquinoxalines

Publication
Bioorg. Med. Chem. Lett. 2015, 25 (22), 5326-5330
Year
2015
Customer
Dr. August Wolff
Symeres authors
Peter Molenveld, Renaud Bouzanne des Mazery, Geert Jan Sterk, Roy Storcken, Reshma Autar, Bram van Ossa, Richard van der Haas
Publication

Cyclopentitol as a scaffold for a natural product-like compound library for drug discovery

Publication
Bioorg. Med. Chem. 2015, 23 (11), 2650-2655
Year
2015
Customer
Leinden Institute of Chemicals
Symeres authors
Sjoerd Aertssen, Remco Beuving, Jorg Benningshof
 
 

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