Methylation of geometrically constrained lysine analogues by histone lysine methyltransferases

Publication

Pharmacokinetic Modeling of [11C]GSK-189254, PET Tracer Targeting H3 Receptors, in Rat Brain

Publication
Mol. Pharmaceutics 2022, 19, 3, 918–928
Year
2022
Customer
UMCG
Symeres authors
Maria Kominia, Martin Koelewijn
Publication

Large-Scale Cyclopropanation of Butyl Acrylate with Difluorocarbene and Classical Resolution of a Key Fluorinated Building Block

Publication
Org. Process Res. Dev. 2022, 26, 3, 683–697
Year
2022
Customer
Pfizer
Symeres authors
Michel Leeman
Publication

α-C-H photoalkylation of a glucose derivative in continuous flow

Publication
Year
2022
Customer
UMC Gronignen
Symeres authors
Marc Mouthaan, Mark Borst, Kees Pouwer
Publication

A New Class of Tunable Acid-Sensitive Linkers for Native Drug Release Based on the Trityl Protecting Group

Publication
Bioconjugate Chem. 2022, XXXX, XXX, XXX-XXX
Year
2022
Customer
Cristal Therapeutics
Symeres authors
Roel Bell, Peter Lenting
Publication

TMTHSI, a superior 7-membered ring alkyne containing reagent for strain-promoted azide–alkyne cycloaddition reactions

Publication
Chemical Science 2022, 33
Year
2022
Customer
Cristal Therapeutics
Symeres authors
Harald Veldhuis, Tommi Meulemans
Publication

Discovery of 2,4-1H-Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors

Publication
ACS Medicinal Chemsitry Letters, coming soon
Year
2021
Customer
X-Chem, Inc.
Symeres authors
Johan Veerman, Yorik Bruseker, Eddy Damen, Erik Heijne, Wendy van Brugge, Koen Hekking, Rob Winkel, Peter van Rijnsbergen
Publication

Counteracting Enantiospecific Behavior of Tailor-Made Additives During Chiral Symmetry Breaking: Growth Inhibition versus Solid-Solution Formation

Publication
Isr. J. Chem. 2021, 61, 1 – 6
Year
2021
Customer
Ardena
Symeres authors
Michel Leeman, Richard Kellogg
Publication

Resolution of a Metastable Racemic Compound of Anhydrous Phencyphos by Hydrate Formation

Publication
Crystals 2021 (11), 1225
Year
2021
Customer
Symeres
Symeres authors
Michel Leeman and Richard M. Kellogg
Publication

Exploration of a Nitromethane-Carbonylation Strategy during Route Design of an Atropisomeric KRASG12C Inhibitor

Publication
J. Org. Chem. 2021
Year
2021
Customer
AstraZeneca
Symeres authors
Cati Ferrer
Publication

A new approach to produce [18F]MC225 via one-step synthesis, a PET radiotracer for measuring P-gp function

Publication
Khaled Attia, John Carlo Sembrano, Olivier Jacquet, Ton Visser
Year
2021
Customer
UMCG
Symeres authors
Garcia-Varela et al. EJNMMI Radiopharmacy and Chemistry (2021) 6:24
 
 

Development Centres of Excellence Network Lead Optimization Hit Generation Lead Optimization
 
 
 
 
 

Development Centres of Excellence Network Lead Optimization Hit Generation Lead Optimization
 
 
 
Scroll to top