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ADME-Tox

We can support your multiparameter medicinal chemistry optimization even further with our high quality in vitro ADME-Tox profiling platform and in vivo DMPK services.​

We offer a co-located early ADME panel with our medicinal chemistry laboratories in the Netherlands to support our integrated optimization projects, as well as a larger suite of customizable in vitro ADME-Tox and in vivo DMPK  services at our Admescope laboratories in Finland and Sweden.

It is crucial to conduct the right studies at the right time to save costs and reduce the risk for failure at later stages of a project. ​


Our ADME-Tox Services

Physicochemistry and binding

Physicochemical parameters give information about the “drug-likeness” of the compound, with respect to absorption from the intestine. Information about these properties is also valuable when planning optimum conditions for other in vitro ADME assays.

​Permeability and transporters

Several assays are available for evaluating permeability and identifying drug transporter substrates or inhibitors.

In vitro metabolism

Aided by the latest technologies and equipment, and with consolidated experience in the field, Symeres is a trusted partner for the synthesis and delivery of highly complex molecules.

Drug Interactions

Evaluating drug-drug interaction risk is a crucial part of drug safety evaluation required by the drug regulatory authorities. The available services cover the identification of metabolising enzymes, enzyme inhibition and enzyme induction assays, as well as transporter-mediated drug-drug interactions.

In vitro toxicology

Information about in vitro toxicity early on during the drug discovery process support your internal decision making. The available non-GLP in vitro toxicology assays are planned for cost-efficient screening with low compound consumption and cover the most commonly faced toxicity related challenges.

In vivo drug metabolism and pharmacokinetics

The in vivo DMPK services cover a variety of animal experiments in several species. In-house rodent PK studies are carried out in AAALAC accredited animal facilities and studies with other species are completed together with selected European in-life partners.

Safety metabolism and in vivo MetID

Safety metabolism studies help you to confirm that the exposure to human metabolites is adequate in preclinical safety species, or to effectively identify potential MIST (metabolites in safety testing) issues in time, through a battery of different types of in vivo MetID studies.

Contract Research Synthesis

Our expertise in synthesis and purification makes us a perfect partner for your chemical challenges. Working with us, we provide you with synthesis teams as a flexible extension of your own department.

Custom Synthesis

In our state-of-the-art laboratories, we perform chemical synthesis from milligram to kilogram scale. Compound classes vary from very small volatiles to high-molecular-weight conjugates (28,000 Da), and lipohilic oils to water-soluble fragments.

Innovative Technologies

Aided by the latest technologies and equipment, and with consolidated experience in the field, Symeres is a trusted partner for the synthesis and delivery of highly complex molecules.

Chiral technologies

Symeres is involved in the latest developments in the field of chirality, ranging from enantioselective synthesis to attrition-enhanced kinetic resolutions. We are world leaders in developing classical resolution processes and inventors of the Dutch resolution.

 
 

Development Centres of Excellence Network Lead Optimization Hit Generation Lead Optimization
 
 
 
 
 

Development Centres of Excellence Network Lead Optimization Hit Generation Lead Optimization
 
 
 
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