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Publication

Discovery of oxazoline enhancers of cellular progranulin release

Publication
Bioorg. Med. Chem. Lett. 80 (2023), 129048
Year
2023
Customer
Arkuda Therapeutics
Symeres authors
Steven Hoekman, Ondrej Longin, Henk Regeling, Wim Zonneveld, Roel Bell
Publication

Extrahepatic in vitro metabolism of peptides; comparison of human kidney and intestinal S9 fraction, human plasma and proximal tubule cells, using cyclosporine A, leuprorelin, and cetrorelix as model compounds

Publication
J Pharmaceut Biomed 225 (2023) 115219
Year
2023
Customer
University of Oulu
Symeres authors
Juha Jyrkäs, Ari Tolonen
Publication

Amino Acid-Metabolizing Enzymes in Advanced High-Grade Serous Ovarian Cancer Patients: Value of Ascites as Biomarker Source and Role for IL4I1 and IDO1 (Oncolines publication)

Publication
Cancers 2023, 15(3), 893
Year
2023
Customer
Radboud University Medical Center and Pangaea Oncology
Symeres authors
(Oncolines) Yvonne Grobben, Guido Zaman
Publication

Rapid deracemization through solvent cycling: proof-of-concept using a racemizable conglomerate clopidogrel precursor

Publication
Chem. Commun., 2023,59, 3838-3841
Year
2023
Customer
AMOLF institute
Symeres authors
Michel Leeman, Richard Kellog
Publication

Feasibility Study to Assess Canagliflozin Distribution and Sodium-Glucose Co-Transporter 2 Occupancy Using [18 F]Canagliflozin in Patients with Type 2 Diabetes

Publication
Clin. Pharmacol. Ther. 2023 Mar 10
Year
2023
Customer
UMCG
Symeres authors
Ton Visser, Andre Heeres
Publication

Contemporary Chiral Resolutions

Publication
Chimica Oggi - Chemistry Today 2023 (41)
Year
2023
Customer
Symeres
Symeres authors
Michel Leeman
Publication

Pharmacokinetic Modeling of [11C]GSK-189254, PET Tracer Targeting H3 Receptors, in Rat Brain

Publication
Mol. Pharmaceutics 2022, 19, 3, 918–928
Year
2022
Customer
UMCG
Symeres authors
Maria Kominia, Martin Koelewijn
Publication

Large-Scale Cyclopropanation of Butyl Acrylate with Difluorocarbene and Classical Resolution of a Key Fluorinated Building Block

Publication
Org. Process Res. Dev. 2022, 26, 3, 683–697
Year
2022
Customer
Pfizer
Symeres authors
Michel Leeman
Publication

α-C-H photoalkylation of a glucose derivative in continuous flow

Publication
Year
2022
Customer
UMC Gronignen
Symeres authors
Marc Mouthaan, Mark Borst, Kees Pouwer
Publication

A New Class of Tunable Acid-Sensitive Linkers for Native Drug Release Based on the Trityl Protecting Group

Publication
Bioconjugate Chem. 2022, 33, 9, 1707–1715
Year
2022
Customer
Cristal Therapeutics
Symeres authors
Roel Bell, Peter Lenting
 
 

Development Centres of Excellence Network Lead Optimization Hit Generation Lead Optimization
 
 
 
 
 

Development Centres of Excellence Network Lead Optimization Hit Generation Lead Optimization
 
 
 
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