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Publication

π-Facial selectivity in the Diels–Alder reaction of glucosamine-based chiral furans and maleimides

Publication
Org. Biomol. Chem., 2023, Advance Article
Year
2022
Customer
University of Groningen, Department of Chemical Biology, Stratingh Institute for Chemistry
Symeres authors
Kees van der Loo, Mark Borst, Kees Pouwer
Publication

Comparative kinase and cancer cell panel profiling of kinase inhibitors approved for clinical use from 2018 to 2020 (Oncolines publication)

Publication
Front. Oncol., Sec. Cancer Molecular Targets and Therapeutics 12 - 2022
Year
2022
Customer
NTRC
Symeres authors
(Oncolines) Jeffrey Kooijman, Helma Simons-van Riel, Jelle Dylus, Yvonne Grobben, Tessa de Bitter, Antoon van Doornmalen, Janneke Melis, Jeroen de Roos, Nicole Willemsen-Seegers, Guido Zaman
Publication

The Tankyrase Inhibitor OM-153 Demonstrates Antitumor Efficacy and a Therapeutic Window ] in Mouse Models

Publication
Cancer Research Communications (2022) 2 (4): 233–245.
Year
2022
Customer
Oslo University
Symeres authors
Ruben Leenders, Anita Wegert
Publication

Discovery of 2,4-1H-Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors

Publication
ACS Medicinal Chemsitry Letters, coming soon
Year
2021
Customer
X-Chem, Inc.
Symeres authors
Johan Veerman, Yorik Bruseker, Eddy Damen, Erik Heijne, Wendy van Brugge, Koen Hekking, Rob Winkel, Peter van Rijnsbergen
Publication

Counteracting Enantiospecific Behavior of Tailor-Made Additives During Chiral Symmetry Breaking: Growth Inhibition versus Solid-Solution Formation

Publication
Isr. J. Chem. 2021, 61, 1 – 6
Year
2021
Customer
Ardena
Symeres authors
Michel Leeman, Richard Kellogg
Publication

Resolution of a Metastable Racemic Compound of Anhydrous Phencyphos by Hydrate Formation

Publication
Crystals 2021 (11), 1225
Year
2021
Customer
Symeres
Symeres authors
Michel Leeman and Richard M. Kellogg
Publication

Exploration of a Nitromethane-Carbonylation Strategy during Route Design of an Atropisomeric KRASG12C Inhibitor

Publication
J. Org. Chem. 2021
Year
2021
Customer
AstraZeneca
Symeres authors
Cati Ferrer
Publication

A new approach to produce [18F]MC225 via one-step synthesis, a PET radiotracer for measuring P-gp function

Publication
Khaled Attia, John Carlo Sembrano, Olivier Jacquet, Ton Visser
Year
2021
Customer
UMCG
Symeres authors
Garcia-Varela et al. EJNMMI Radiopharmacy and Chemistry (2021) 6:24
Publication

GMP Compliant Synthesis of [18F]Canagliflozin, a Novel PET Tracer for the Sodium−Glucose Cotransporter 2

Publication
J. Med. Chem. (2021), 64, 22, 16641–16649
Year
2021
Customer
UMCG
Symeres authors
Olivier Jacquet, Ton Visser, Andre Heeres, Khaled Attia
Publication

Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II

Publication
J. Med. Chem. 2021, 64, 24, 17936–17949
Year
2021
Customer
Oslo university
Symeres authors
Ruben Leenders, Sjoerd Aertssen, Piotr Nieczypor, Eddy Damen, Anita Wegert
 
 

Development Centres of Excellence Network Lead Optimization Hit Generation Lead Optimization
 
 
 
 
 

Development Centres of Excellence Network Lead Optimization Hit Generation Lead Optimization
 
 
 
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