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Publication

Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation

Publication
Drug Design, Development and Therapy 2019, 13, 345-364
Year
2019
Customer
VU UMC, UMCG, Chaperone Pharma
Site
Groningen
Department
Discovery
MCS people
Jean-Paul Seerden, Lizette Loen, Andre Heeres
Publication

Bivalent Ligands for Protein Degradation in Drug Discovery

Publication
Comp. and Struc. Biotech. J., (17), 2019, 160-176
Year
2019
Customer
MercachemSyncom
Site
Nijmegen
Department
Discovery
MCS people
Marcel Scheepstra, Koen Hekking, Luc van Hijfte, Rutger Folmer
Publication

Novel SAR for quinazoline inhibitors of EHMT1 and EHMT2

Publication
Bioorganic & Medicinal Chemistry Letters, 2019, (17), 2516-2524
Year
2019
Customer
Eurostar grant, with Proqinase
Site
Nijmegen
Department
Discovery
MCS people
Ruben Leenders, Remco Zijlmans, Bart van Bree, Marc van de Sande, FedericaTrivarellia, Eddy Damen, Anita Wegert, Gerhard Müller
Publication

Fast Iterative Synthetic Approach toward Identification of Novel Highly Selective p38 MAP Kinase Inhibitors

Publication
J. Med. Chem, 2019 (62), 10757-10782
Year
2019
Customer
Goethe University Frankfurt
Site
Nijmegen
Department
Discovery
MCS people
Rob Winkel, Koen Hekking, Jorg Benningshof
Publication

A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam

Publication
Organic & Biomolecular Chemistry, 2019, 17, 35-38
Year
2019
Customer
AMOLF
Site
Groningen
Department
MCS people
Michel Leeman, Richard Kellogg,
Publication

A chiral switch: balancing between equilibrium and non-equilibrium states

Publication
Chem. Comm, 2019, in press
Year
2019
Customer
AMOLF
Site
Groningen
Department
MCS people
Michel Leeman, Richard Kellogg
Publication

Structure–Activity Relationship Studies on (R)-PFI-2 Analogues as Inhibitors of Histone Lysine Methyltransferase SETD7

Publication
ChemMedChem, 2018, 13, 1405 – 1413
Year
2018
Customer
Institute for Molecules and Materials
Site
Nijmegen
Department
Discovery
MCS people
Eddy Damen, Ruben Leenders, Richard Blaauw
Publication

Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity

Publication
Journal of Medicinal Chemistry, 2018, 61, (9), 3870-3888
Year
2018
Customer
TI Pharma
Site
Nijmegen
Department
Discovery
MCS people
Johan Veerman, Toine van de Bergh
Publication

Microwave-assisted diastereoselective two-step three-component synthesis for rapid access to drug-like libraries of substituted 3-amino-β-lactams

Publication
Bioorg. Med. Chem. 2018, 26, 41-49
Year
2018
Customer
Leiden University Medical Center
Site
Nijmegen
Department
Discovery
MCS people
Joyce van den Heuvel, Rik Megens, Jorg Benningshof
Publication

The Strecker reaction coupled to Viedma ripening: a simple route to highly hindered enantiomerically pure amino acids

Publication
Chem. Comm., 2018, 54, 10832-10834
Year
2018
Customer
AMOLF
Site
Groningen
Department
MCS people
Michel Leeman, Richard Kellogg

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