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Publication

Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor

Publication
J. Med. Chem. 2020, 63, 6834-6846
Year
2020
Customer
Oslo University
Symeres authors
Ruben Leenders, Piotr Nieczypor, Sjoerd Aertsen, Eddy Damen, Anita Wegert
Publication

The synthesis of 13C6-labeled l-thyronine, 3,5-diiodothyronine, 3,3′,5-triiodothyroacetic acid and 3,3′,5,5′-tetraiodothyroacetic acid

Publication
Tetrahedron 2020 (76), 33, 131352
Year
2020
Customer
Erasmus MC
Symeres authors
Gregor Pilzak, Toine van den Bergh, Tommi Meulemans
Publication

Performance Analysis and Model-Free Design of Deracemization via Temperature Cycles

Publication
Org. Process Res. Dev. 2020
Year
2020
Customer
ETH institute
Symeres authors
Michel Leeman, Richard Kellogg
Publication

Enantiospecific Solid Solution Formation Triggers the Propagation of Homochirality

Publication
Angew. Chem. Int. Ed. 2020, 59, 1 – 6
Year
2020
Customer
AMOLF
Symeres authors
Michel Leeman, Richard Kellogg
Publication

Scalable Synthesis of 17S-FD-895 Expands the Structural Understanding of Splice Modulatory Activity

Publication
Cell Reports Physical Science 2020 (1), 12, 100277
Year
2020
Customer
UCSD
Symeres authors
Mark Verhaar, Martijn Slagt, Dominika Bachera, Minze Rispens, Remco Hofman, Vincent de Boer, Rory van der Hulst Rutger Bus, Pieter Hiemstra
Publication

Modular Medical Imaging Agents Based on Azide–Alkyne Huisgen Cycloadditions: Synthesis and Pre-Clinical Evaluation of 18F-Labeled PSMA-Tracers for Prostate Cancer Imaging

Publication
Chemistry A European Journal 27, 23, 6993
Year
2020
Customer
Dutch Provinces Overijssel and Gelderland
Symeres authors
Marten Klopstra, Ton Visser, Keimpe-Oeds van den Berg
Publication

Methylation of geometrically constrained lysine analogues by histone lysine methyltransferases

Publication
Chem. Commun. (2020), 56(20), 3039-3042
Year
2020
Customer
Chiralix
Symeres authors
Richard Blaauw
Publication

Bivalent Ligands for Protein Degradation in Drug Discovery

Publication
Comp. and Struc. Biotech. J., (17), 2019, 160-176
Year
2019
Customer
MercachemSyncom
Symeres authors
Marcel Scheepstra, Koen Hekking, Luc van Hijfte, Rutger Folmer
Publication

Novel SAR for quinazoline inhibitors of EHMT1 and EHMT2

Publication
Bioorganic & Medicinal Chemistry Letters, 2019, (17), 2516-2524
Year
2019
Customer
Eurostar grant, with Proqinase
Symeres authors
Ruben Leenders, Remco Zijlmans, Bart van Bree, Marc van de Sande, FedericaTrivarellia, Eddy Damen, Anita Wegert, Gerhard Müller
Publication

Fast Iterative Synthetic Approach toward Identification of Novel Highly Selective p38 MAP Kinase Inhibitors

Publication
J. Med. Chem, 2019 (62), 10757-10782
Year
2019
Customer
Goethe University Frankfurt
Symeres authors
Rob Winkel, Koen Hekking, Jorg Benningshof
 
 

Development Centres of Excellence Network Lead Optimization Hit Generation Lead Optimization
 
 
 
 
 

Development Centres of Excellence Network Lead Optimization Hit Generation Lead Optimization
 
 
 
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