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Publication

A chiral switch: balancing between equilibrium and non-equilibrium states

Publication
Chem. Comm, 2019, in press
Year
2019
Customer
AMOLF
Site
Groningen
Department
MCS people
Michel Leeman, Richard Kellogg
Publication

Structure–Activity Relationship Studies on (R)-PFI-2 Analogues as Inhibitors of Histone Lysine Methyltransferase SETD7

Publication
ChemMedChem, 2018, 13, 1405 – 1413
Year
2018
Customer
Institute for Molecules and Materials
Site
Nijmegen
Department
Discovery
MCS people
Eddy Damen, Ruben Leenders, Richard Blaauw
Publication

Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity

Publication
Journal of Medicinal Chemistry, 2018, 61, (9), 3870-3888
Year
2018
Customer
TI Pharma
Site
Nijmegen
Department
Discovery
MCS people
Johan Veerman, Toine van de Bergh
Publication

Microwave-assisted diastereoselective two-step three-component synthesis for rapid access to drug-like libraries of substituted 3-amino-β-lactams

Publication
Bioorg. Med. Chem. 2018, 26, 41-49
Year
2018
Customer
Leiden University Medical Center
Site
Nijmegen
Department
Discovery
MCS people
Joyce van den Heuvel, Rik Megens, Jorg Benningshof
Publication

The Strecker reaction coupled to Viedma ripening: a simple route to highly hindered enantiomerically pure amino acids

Publication
Chem. Comm., 2018, 54, 10832-10834
Year
2018
Customer
AMOLF
Site
Groningen
Department
MCS people
Michel Leeman, Richard Kellogg
Publication

Synthesis of yellow fluorescent dyes derived from benzoxanthene that can be used in colour converters for remote phosphor LED systems

Publication
Dyes and pigments, 2018, 149, 662-668
Year
2018
Customer
Philips
Site
Groningen
Department
MCS people
Sylvain Hamon, Ton Visser
Publication

Drug-target residence time: A misleading concept

Publication
Drug Discovery 23, 1, (2018,) 12-16
Year
2018
Customer
Site
Nijmegen
Department
Discovery
MCS people
Rutger folmer
Publication

A multi-gram-scale stereoselective synthesis of Z-endoxifen

Publication
Bioorg. Med. Chem. Lett 28 (2018) 1352–1356
Year
2018
Customer
TU eindhoven
Site
Groningen
Department
Discovery
MCS people
Bartjan Koning, Jan Koek
Publication

Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors

Publication
J. Med. Chem. 2017, 60 (17), 7371-7392
Year
2017
Customer
Galapagos
Site
Nijmegen
Department
Discovery
MCS people
Jörg Heiermann, Willem Hengelveld, Gregor Pilzak
Publication

Design and Synthesis of Enantiomerically Pure Decahydroquinoxalines as Potent and Selective k-Opioid Receptor Agonists with Anti-Inflammatory Activity in Vivo

Publication
J. Med. Chem. 2017, 60 (6), 2526-2551
Year
2017
Customer
Dr. August Wolff
Site
Nijmegen
Department
Discovery
MCS people
Peter Molenveld, Roy Storcken, Renaud Bouzanne des Mazery, Geert-Jan Sterk, Reshma Autar, Marjon Bolster, Clemens Wagner, Frank van Holst, Anita Wegert

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