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Publication

Drug-target residence time: A misleading concept

Publication
Drug Discovery 23, 1, (2018,) 12-16
Year
2018
Customer
Symeres authors
Rutger folmer
Publication

A multi-gram-scale stereoselective synthesis of Z-endoxifen

Publication
Bioorg. Med. Chem. Lett 28 (2018) 1352–1356
Year
2018
Customer
TU eindhoven
Symeres authors
Bartjan Koning, Jan Koek
Publication

Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors

Publication
J. Med. Chem. 2017, 60 (17), 7371-7392
Year
2017
Customer
Galapagos
Symeres authors
Jörg Heiermann, Willem Hengelveld, Gregor Pilzak
Publication

Design and Synthesis of Enantiomerically Pure Decahydroquinoxalines as Potent and Selective k-Opioid Receptor Agonists with Anti-Inflammatory Activity in Vivo

Publication
J. Med. Chem. 2017, 60 (6), 2526-2551
Year
2017
Customer
Dr. August Wolff
Symeres authors
Peter Molenveld, Roy Storcken, Renaud Bouzanne des Mazery, Geert-Jan Sterk, Reshma Autar, Marjon Bolster, Clemens Wagner, Frank van Holst, Anita Wegert
Publication

Charting Biologically Relevant Spirocyclic Compound Space

Publication
Chem. Eur. J. 2017, 23 (3), 703-710
Year
2017
Customer
ELF
Symeres authors
Gerhard Müller, Tim Berkenbosch, Jorg Benningshof
Publication

Synthesis and Properties of 2-Oxa-6-azaspiro[3.3]heptane Sulfonate Salts

Publication
Synthesis 2017, 49 (11), 2394-2401
Year
2017
Customer
Bayer Pharma
Symeres authors
Richard van der Haas, Jeroen Dekker, Eric Damen
Publication

Piperidine and octahydropyrano[3,4-c] pyridine scaffolds for drug-like molecular libraries of the European Lead Factory

Publication
Bioorg. Med. Chem. 2017, 5160 - 5170
Year
2017
Customer
Leiden Institute of Chemistry
Symeres authors
Dirk Vandenput, Joeri Scheidt, Jorg Benningshof
Publication

Synthesis and evaluation of analogs of the phenylpyridazinone NPD-001 as potent trypanosomal TbrPDEB1 phosphodiesterase inhibitors and in vitro trypanocidal

Publication
Bioorg. Med. Chem. 2016, 24 (7), 1573-1581
Year
2016
Customer
VU
Symeres authors
Johan Veerman, Toine van den Bergh, Geert-Jan Sterk
Publication

Securing Important Strigolactone Key Structures: Orobanchol and 5-Deoxystrigol

Publication
Eur. J. Org. Chem. 2016 (12), 2163–2169
Year
2016
Customer
Radboud University
Symeres authors
Colinda van Tilburg‐Joukema, Bram van Oss, Peter Molenveld
Publication

Strategic and tactical approaches to the synthesis of 5,6-dihydro-[1,2,4]oxadiazines

Publication
Heterocycles 2016, 92 (12), 2166-2200.
Year
2016
Customer
Mercachem
Symeres authors
Johan Veerman, Yorik Bruseker, Bart van Esseveldt, Erik Heijne, Tommi Meulemans, Peter van Rijnsbergen, Wim Zonneveld
 
 

Development Centres of Excellence Network Lead Optimization Hit Generation Lead Optimization
 
 
 
 
 

Development Centres of Excellence Network Lead Optimization Hit Generation Lead Optimization
 
 
 
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