We are the leading transatlantic small molecule contract research and manufacturing organization that has been a trusted global partner for biotech and pharma companies for over 30 years.
About us

Why work with us?
What do our clients say?
Hear firsthand accounts of how we’re driving success in our customers’ programs!
“Through our dedicated FTE resource at Symeres we have achieved remarkable results, not only by developing a new “aspirational” synthetic route but also by significantly improving the current one to deliver a sustainable route for commercial production and giving us two options for late development.”
– Associate Director, Large Pharma, Europe
“If the compound can be made, Symeres will undoubtedly find out a good way to make it.”
– Dooyoung Jung, CEO of Pinotbio
“The progression was really phenomenal. I am truly impressed. There is a world of difference between you and other CROs.”
– Biotech Start-up Founder
Latest news
Below are a few of our most recent news items.
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Symeres and Yoneda Labs Use AI to Optimize Cross-Coupling Reactions
San Francisco, May 29, 2025 – Yoneda Labs, a leader in computational tools for reaction optimization, has successfully collaborated with Symeres, a leading transatlantic, small molecule contract research and manufacturing organization. The aim was to optimize transition metal catalyzed cross-coupling reactions to improve reaction yield and efficiency utilizing Yoneda Labs’ cutting-edge software.
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J. Med. Chem. Publication: Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II
In this follow-up article, co-published with Oslo University Hospital, we report further development and optimization of 1,2,3-triazole-based tankyrase inhibitors. Through X-ray crystallography supported SAR analysis, we synthesized a series of novel TNKS inhibitors with improved ADME/PK profiles, exhibiting antiproliferative efficacy in colorectal cancer cell lines. Click on the link below for a short summary of this publication.
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Meet the Organix Director, Mario Gonzalez
We are pleased to share a conversation with Dr. Mario Gonzalez, a Director at Organix, as he reflects on his journey from Argentina to Massachusetts and provides valuable career insights in celebration of his 30 years with the company.
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New Production Lines D1 and D2 at our Prague site!
The new production lines D1 and D2 were launched for the first time in May 2024 at the Prague site. The first batch of 11 kg of API was produced in the following weeks, and the tremendous efforts of the many people involved in planning the entire production line have finally paid off. Since the production line was launched, all equipment has been continuously utilized.
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Reliable Tablet Formulation at Exemplify!
We at Symeres pride ourselves on a stellar track record in drug-substance development. For our clients that are looking to rapidly move through phase-appropriate clinical tablet formulation development, Exemplify is the perfect place to start for small-scale to large-scale pharma companies. Our cGMP suites are specially equipped to support everything from pre-tox formulation to first-in-human (FIH) trials and commercially ready formulation.
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Peter Molenveld’s 25th Anniversary with Symeres
Recently, our colleague Peter Molenveld celebrated his 25th anniversary with Symeres. Peter participated in an interview where he shared about his time with Symeres and his growth here as a chemist to leadership within the organization, as well as about his role as secretary at the Royal Netherlands Chemical Society (KNCV).
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New NMR Technology – Meet “Maggie”
Nuclear Magnetic Resonance (NMR) Spectroscopy is a powerful analytical tool well known to all organic chemists and to anyone that works in pharmaceuticals. By placing a sample dissolved in deuterated solvent into a strong magnetic field (roughly 4000x the strength of Earth’s magnetic field) and pulsing it with radio frequencies, the chemist is given an enormous amount of information from the identity and placement of functional groups to relative stereochemistry of diastereomers. Recently, Exemplify added NMR to our expanding list of capabilities.
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Symeres announces leadership evolution
Symeres announces the evolution of its leadership team ahead of the company’s next phase of development. After nearly three decades at the helm, Symeres’ co-founders, Dr. Eelco Ebbers (CEO) and Dr. Frank Leemhuis (Head of Corporate Development), have decided to step back from their current executive roles.
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Official opening of new Oncolines home, the Marie Curie Building at the Pivot Park in Oss, The Netherlands
After months of dedication and collaboration, the official opening of the Marie Curie building at the Pivot Park in Oss was opened on Sep 19th, 2024. The Marie Curie building is a multitenant laboratory building which houses Oncolines B.V., the in vitro biology services laboratory of Symeres. Read more about this exciting development!
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J. Med. Chem. Publication: Preclinical Lead Optimization of a 1,2,4-Triazole-Based Tankyrase Inhibitor
In collaboration with Oslo University Hospital, we report the synthesis and biological activity of novel 1,2,3-triazole-based tankyrase inhibitors. Through a modular synthetic pathway and X-ray crystallography supported SAR analysis, we synthesized a series of novel TNKS inhibitors with improved ADME profiles, exhibiting antiproliferative efficacy in colorectal cancer cell lines. Click on the link below for a short summary of this publication.
Read more
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New video of our Solid-State Center of Excellence
In this new video our colleagues Gabriella Pizutti, Chantalle van Berkel, and Eva Verhofstad, will give you an exciting lab tour through the Symeres Solid-State Centre of Excellence, located at the Symeres site in Weert, the Netherlands. You will learn more about PhysChem Properties, Solid Form Screening, Crystallization, Crystal Habit, Pre-formulation, and Formulation. Feel free to contact us via the contact form on this website if you would like to learn more about our Solid-State capabilities.
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New equipment at Exemplify
Exemplify has recently acquired a Mettler-Toledo EasyMax 402 automated reactor system to add to its process development capabilities. This instrument can accommodate reactor sizes of 100 and 400 mL and allows for the precise automated control of reaction parameters such as temperature, stirring speed, reagent addition rate, and pH, providing real-time data collection that can greatly enhance our understanding of a reaction’s unique profile.
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New 100 L vessels in Groningen
The first of the two new 100 L glass-lined stainless steel reactor lines has successfully finished the testing and now it is operational at our Groningen site. By doubling our batch size capacity, we have increased the efficiency for large-scale non-GMP production projects. This will result in faster delivery times for our clients and less batch routine work for our chemists.
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Organix: New facility
On March 26th we had the Grand Opening of our brand new, state-of-the-art Organix synthetic and analytical chemistry laboratories in Woburn, just outside Boston MA.
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Towards Multitargeted Ligands as Pain Therapeutics: Dual Ligands of the Cavα2δ-1 Subunit of Voltage-Gated Calcium Channel and the μ-Opioid Receptor
In collaboration with WeLab Barcelona, we report the synthesis and biological activity of novel pain therapeutics, which target both Cavα2δ-1 and MOR. One of these disubstituted pyrrolidines demonstrated an analgesic effect in various rodent models of pain, and a lack of unfavorable off-target interactions, showing no evident signs of withdrawal or tolerance. Click on the link below for a short summary of this publication.
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Innovative macrocycles as powerful Mcl-1 inhibitors
This is a recap of the article “Development of potent Mcl-1 inhibitors: structural investigations on macrocycles originating from a DNA-encoded chemical library screen” published in the Journal of Medicinal Chemistry. Myeloid cell leukemia 1 (Mcl-1) is a protein that plays a crucial role in the regulation of cell survival and cell death. It is part of a family of proteins called the Bcl-2 family, which are known for their involvement in controlling the life span of cells.
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Oncolines unveils new State-of-the-Art Laboratories
In a significant stride towards advancing cancer research and drug development, Oncolines, has officially received the keys to its new laboratories and offices situated within the prestigious Curie Building on the Pivot Park in Oss, the Netherlands.
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Our Article Published in the Journal of Medicinal Chemistry
Symeres is thrilled to announce the publication of a scientific article in the prestigious Journal of Medicinal Chemistry with our colleague Koen Hekking as the main author and many more Symerians involved! We are incredibly proud of our colleagues who were instrumental in the research and development of this innovative project.
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Peter Molenveld Assumes Role as Secretary of KNCV (Royal Netherlands Chemical Society)
Symeres is proud to announce that our colleague Dr. Peter Molenveld has been appointed as a board member of the Royal Netherlands Chemical Society (KNCV). His appointment as Secretary marks a crucial milestone in Molenveld’s career and signifies his commitment to advancing the interests of the chemical community in the Netherlands.
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Interview with the Computer-Aided Drug Design (CADD) Department
Our Computer Aided Drug Design department supports our clients’ drug discovery projects with some of the best (predictive) software.
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“If the compound can be made, Symeres will undoubtedly find out a good way to make it.” Dooyoung Jung, CEO of Pinotbio.
An in-depth interview with Doo Young Jung, the founder and CEO of our client Pinotbio in South Korea, focused on the challenge of cancer resistance/relapse
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New scientific services from Symeres
We’re proud to announce that our brand new CMC facility at the Exemplify site of Symeres in New Jersey has been successfully completed. GMP drug product R&D facilities that will allow it to provide end-to-end services ranging from GMP and non-GMP drug product development to phase 1 and 2 clinical supplies of various oral, parenteral, and topical formulation dosage forms.
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Latest events
Symeres actively participates in many international Life Sciences conferences. See below for some of the upcoming events where you can meet us and discuss your R&D services needs.
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ACSMEDI-EFMC Medicinal Chemistry Frontiers 2025
12-15 May
Chicago, ILRead more
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Hosting the Dutch Chemistry Olympiad 2025
30 May – 7 June
Nijmegen and Groningen, NetherlandsRead more
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Discovery and Development Europe 2025
23-24 June
Basel, SwitzerlandRead more
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EFMC-ASMC 2025
31 Aug – Sept 4
Porto, PortugalRead more
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Chem Outsourcing 2025
2-5 Sep
Parsippany, NJ USARead more
Feel free to contact us!
Curious to know more about what can we do for you? Get in touch and let’s start a conversation.