Ruthenium Bis-Sulfonate Complexes: Synthesis and Application in Asymmetric Hydrogenation
Reference: Y. Zhou, P. Vink, I. Kılınç, O. O. Sokolova, F. M. Miloserdov. Ruthenium Bis-Sulfonate Complexes: Synthesis and Application in Asymmetric Hydrogenation. Organometallics (2025). DOI: 10.1021/acs.organomet.5c00388.
2026
Synthesis and absolute configuration of the sesquiterpene lactone EPD, a natural product with broad antitumor cell activity via a unique mechanism of action
Reference: J.Nat.Prod.2025,88,1766−1771
2025
Discovery and preclinical evaluation of PBX-7016, a Methylenedioxy-Camptothecin payload for antibody-drug conjugates with enhanced therapeutic potential
Reference: J. Med. Chem. 2026, 69, 1, 413–438
Customer: Pinotbio
2025
Exploration of a nitromethane-carbonylation strategy during route design of an atropisomeric KRASG12C inhibitor
Reference: J. Org. Chem. 2021
Symeres authors: Cati Ferrer
Customer: AstraZeneca
2025
Rare case of polymorphism in the binary system of enantiomers of a praziquantel derivative
Reference: Org. Process Res. Dev. 2024, 28, 4, 1224–1232
Symeres author: Michel Leeman
Customer: University of Rouen
2024
Development of potent Mcl-1 Inhibitors: Structural investigations on macrocycles originating from a DNA-encoded chemical library screen
Reference: J. Med. Chem. 2024 (67), 3039-3065
Symeres authors: Koen Hekking, Marjon Bolster, Sergio Maroto, Kees van Kekem, Frank Haasjes, Jack Slootweg, Patrick Oude Alink, Ron Dirks, Brian Kuijpers, Robin Doodeman, Dennis Smith
2024
Silicon-based linkers for tunable acid-sensitive drug release from polymeric nanoparticles
Reference: Chemistry Europe. 2024 Dec 11:e202403589
Symeres authors: Tommi Meulemans and Peter Schuckman
Customer: Cristal Therapeutics
2024
Towards multitargeted ligands as pain therapeutics: Dual ligands of the Cavα2δ-1 subunit of voltage-gated calcium channel and the μ-opioid receptor
Reference: ChemMedChem 2024, e202300473
Symeres authors: Anita Wegert, Wouter de Graaf, Frank van Holst, Giovanni Bolcato
Customer: WeLab Barcelona
2024
High target homology does not guarantee inhibition: Aminothiazoles emerge as inhibitors of plasmodium falciparum
Reference: ACS Infect. Dis. 2024, 10, 1000−1022
Symeres authors: Melloney Dröge, Bernard van Vliet, Jack den Hartog
2024
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