Discovery and preclinical evaluation of PBX-7016, a Methylenedioxy-Camptothecin payload for antibody-drug conjugates with enhanced therapeutic potential
Reference: J. Med. Chem. 2025, XXXX, XXX, XXX-XXX
Customer: Pinotbio
2025
Synthesis and absolute configuration of the sesquiterpene lactone EPD, a natural product with broad antitumor cell activity via a unique mechanism of action
Reference: J.Nat.Prod.2025,88,1766−1771
2025
Exploration of a nitromethane-carbonylation strategy during route design of an atropisomeric KRASG12C inhibitor
Reference: J. Org. Chem. 2021
Symeres authors: Cati Ferrer
Customer: AstraZeneca
2025
Rare case of polymorphism in the binary system of enantiomers of a praziquantel derivative
Reference: Org. Process Res. Dev. 2024, 28, 4, 1224–1232
Symeres author: Michel Leeman
Customer: University of Rouen
2024
Development of potent Mcl-1 Inhibitors: Structural investigations on macrocycles originating from a DNA-encoded chemical library screen
Reference: J. Med. Chem. 2024 (67), 3039-3065
Symeres authors: Koen Hekking, Marjon Bolster, Sergio Maroto, Kees van Kekem, Frank Haasjes, Jack Slootweg, Patrick Oude Alink, Ron Dirks, Brian Kuijpers, Robin Doodeman, Dennis Smith
2024
High target homology does not guarantee inhibition: Aminothiazoles emerge as inhibitors of plasmodium falciparum
Reference: ACS Infect. Dis. 2024, 10, 1000−1022
Symeres authors: Melloney Dröge, Bernard van Vliet, Jack den Hartog
2024
Silicon-based linkers for tunable acid-sensitive drug release from polymeric nanoparticles
Reference: Chemistry Europe. 2024 Dec 11:e202403589
Symeres authors: Tommi Meulemans and Peter Schuckman
Customer: Cristal Therapeutics
2024
Towards multitargeted ligands as pain therapeutics: Dual ligands of the Cavα2δ-1 subunit of voltage-gated calcium channel and the μ-opioid receptor
Reference: ChemMedChem 2024, e202300473
Symeres authors: Anita Wegert, Wouter de Graaf, Frank van Holst, Giovanni Bolcato
Customer: WeLab Barcelona
2024
Specific N-terminal attachment of TMTHSI linkers to native peptides and proteins for strain-promoted azide alkyne cycloaddition
Reference: Chem. Commun., 2023, Advance Article
Symeres authors: Niels Hauwert
Customer: Cristal Therapeutics
2023
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