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Synthesis and absolute configuration of the sesquiterpene lactone EPD, a natural product with broad antitumor cell activity via a unique mechanism of action

Reference: J.Nat.Prod.2025,88,1766−1771

 

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Exploration of a nitromethane-carbonylation strategy during route design of an atropisomeric KRASG12C inhibitor

Reference: J. Org. Chem. 2021

Symeres authors: Cati Ferrer

Customer: AstraZeneca

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Rare case of polymorphism in the binary system of enantiomers of a praziquantel derivative

Reference: Org. Process Res. Dev. 2024, 28, 4, 1224–1232

Symeres author: Michel Leeman

Customer: University of Rouen

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Towards multitargeted ligands as pain therapeutics: Dual ligands of the Cavα2δ-1 subunit of voltage-gated calcium channel and the μ-opioid receptor

Reference: ChemMedChem 2024, e202300473
Symeres authors: Anita Wegert, Wouter de Graaf, Frank van Holst, Giovanni Bolcato
Customer: WeLab Barcelona

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High target homology does not guarantee inhibition: Aminothiazoles emerge as inhibitors of plasmodium falciparum

Reference: ACS Infect. Dis. 2024, 10, 1000−1022
Symeres authors: Melloney Dröge, Bernard van Vliet, Jack den Hartog

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Development of potent Mcl-1 Inhibitors: Structural investigations on macrocycles originating from a DNA-encoded chemical library screen

Reference: J. Med. Chem. 2024 (67), 3039-3065

Symeres authors: Koen Hekking, Marjon Bolster, Sergio Maroto, Kees van Kekem, Frank Haasjes, Jack Slootweg, Patrick Oude Alink, Ron Dirks, Brian Kuijpers, Robin Doodeman, Dennis Smith

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Silicon-based linkers for tunable acid-sensitive drug release from polymeric nanoparticles

Reference: Chemistry Europe. 2024 Dec 11:e202403589

Symeres authors: Tommi Meulemans and Peter Schuckman

Customer: Cristal Therapeutics

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Specific N-terminal attachment of TMTHSI linkers to native peptides and proteins for strain-promoted azide alkyne cycloaddition

Reference: Chem. Commun., 2023, Advance Article

Symeres authors: Niels Hauwert

Customer: Cristal Therapeutics

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Chemical, biochemical, cellular, and physiological characterization of Leucettinib-21, a Down Syndrome and Alzheimer’s Disease drug candidate

Reference: J. Med. Chem. 2023, 66, 23, 15648–15670

Symeres authors: Sander Brugman, Edwin Aret, Jan Sadownik, Eva Verhofstad and Dennis Sleegers

Customer: Perha Pharmaceuticals

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