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In vivo PK screening services
We provide rapid in vivo pharmacokinetic (PK) screening studies to evaluate absorption, distribution, metabolism, and excretion (ADME) properties early in discovery. These studies generate decision-ready data on exposure, clearance, bioavailability, and half-life – helping to prioritize compounds and reduce downstream risk.
All the in vivo PK screening studies are conducted at our AAALAC-accredited facilities. Tailored study design aligned with your phase and goals include:
- Fast turnaround single-compound or cassette rodent PK screening studies (IV, SC and PO administration)
- Plasma, CSF and tissue sampling
- Brain exposure studies (in vivo BBB permeability)
- Bioanalysis by LC-MS/MS or UPLC-HR/MS, ligand binding assays, qPCR
- Formulation support and comparison
- In vivo metabolite identification and support for in vivo DMPK strategies
Related services
ADME services delivered by Admescope
All ADME services, including in vitro ADME, in vivo PK screening, in vitro toxicology, in vitro ADME-Tox and in vivo DMPK are performed by Admescope (a Symeres company)
In vivo PK screening that reduces risk
Flexible, phase-appropriate solutions
We tailor study designs from early screening to IND-enabling studies preventing data gaps and rework.
Clear data, fast turnaround
We deliver actionable PK data quickly, enabling timely decision-making to minimize delays in your discovery program.
Integrated discovery-to-development support
Our in vivo PK studies are integrated with broader ADME and DMPK services to give you greater clarity to move forward to human studies.
Integrated ADME services
In vivo PK screening links with in vitro ADME and toxicology services to give you early, connected insights into exposure, safety and drug-drug risks.
Integrated data across studies keep results comparable and your decisions confident.
What do our partners say?
“We are developing the most complex molecule that is built at this time in the world…We work with a lot of CROs, also chemistry CROs, and so far Symeres has done the best job with respect to transparency and also to troubleshoot the problems and find a solution. Over the years we have been really impressed with the work that Symeres has done.”
Founder
Biotech
“I would like to extend my thanks for the excellent work Symeres has done in synthesizing the API for Part 1 of our project. Your communication throughout the process was outstanding, and the sense of urgency with which you operated allowed us to complete this phase promptly and efficiently.”
Leader
Large biotech
“Through our dedicated FTE resource at Symeres we have achieved remarkable results, not only by developing a new “aspirational” synthetic route but also by significantly improving the current one to deliver a sustainable route for commercial production and giving us two options for late development.”
Associate Director
Large pharma, Europe
“A sign that things are going well - we keep coming to you. We’ve given Symeres five or six different projects already. That’s almost unheard of for us.“
Senior Director, Manufacturing
Top 10 global pharma
“The progression was really phenomenal. I am truly impressed. There is a world of difference between you and other CROs.”
Start-up Founder
Biotech
“If the compound can be made, Symeres will undoubtedly find out a good way to make it.”
Dooyoung Jung, CEO
Pinotbio
“The team is making short work of these targets, so we will have to start thinking of some additional targets!”
Director
Biotech
“They’ve always met or exceeded my expectations - that’s why I continue to come back, company after company, year after year.”
Allen Horhota, Vice-President Platform & Delivery
Seamless Therapeutics
“We’ve been with them…over 10 years. The cost, the flexibility - the value is just so strong. That’s why we’ve stuck with them.”
Senior Director, CMC
Biotech
Your discovery and development partner
Symeres supports small-molecule programs from discovery through IND with openness, agility and scientific depth.
Our connected teams in Europe and North America share data transparently, adapt quickly to new results, and stay accountable from first experiments to IND, to keep your progress clear, connected and continuous.
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Speak with our in vitro PK screening experts
Ready to supercharge the discovery and development of your next breakthrough.