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Small molecule drug discovery chemistry
Your chemistry programs stay aligned, efficient, and evidence-driven from design to IND. Our CRO chemistry services link medicinal, computational, synthetic, and specialty chemistry to generate consistent data, comparable results and confident decisions that keep your small-molecule projects moving toward clinical supply.
CRO chemistry services
We offer chemistry support from hit identification through IND and beyond, with material ready for Phase 2 and 3 trials, ensuring smooth scale-up and consistent quality from candidate design to production.
Medicinal chemistry
We run hit-to-lead and lead optimization programs that refine potency, selectivity and ADME performance. With SAR, scaffold design, and predictive modeling, you get high quality candidates ready for clinical advancement.
Learn moreSynthetic chemistry
We deliver synthesis at every scale – from milligrams to multi-kilograms – with consistent chemistry and predictable timelines. Projects run as FTE or fee-for-service, covering library synthesis, route scouting, process development, and GMP drug substance production.
Learn moreComputational chemistry
Our computational chemistry group supports structure-based design, virtual screening, scaffold hopping, and predictive modeling – this speeds up hit discovery and guides medicinal chemistry toward stronger, more developable candidates.
Learn moreSpeciality chemistry
Our advanced techniques including photochemistry-like flow chemistry, chemo- and biocatalysis, isotope labeling chemistry, chiral chemistry, and electrochemistry – give you access to novel scaffolds, cleaner reactions and robust data for scale-up and regulatory readiness
Learn moreYour transatlantic drug discovery partner
Symeres supports small-molecule programs from discovery through IND with openness, agility and scientific depth. Our connected teams in Europe and North America provide medicinal chemistry, computational chemistry, synthetic chemistry, and specialty chemistry services integrated with biology, ADME-tox, and CMC development.
We share data transparently, adapt quickly to new results, and stay accountable from first experiments to IND, to keep your progress clear, connected and continuous. Projects can run as standalone studies or as coordinated, multi-disciplinary programs.
Integrated technologies for smarter drug discovery
Our CRO chemistry services are linked with medicinal chemistry, in vitro pharmacology, solid-state chemistry, phase-appropriate ADME profiling, process development and CMC. We deliver consistent data flow from lead optimization to regulatory studies and early GMP supply supporting clearer decisions to progress your small-molecule programs faster.
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O.N.E Symeres: A practical approach to real-world drug development
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CDMO red flags you can’t ignore: Undefined or shifting project scope
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Accelerating chemical innovation: Unveiling Symeres’ parallel chemistry
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From racemic to pure the art and science of enantiomer separation
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IND & IMPD enabling developability roadmap
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Leveraging copper-catalyzed ullmann-type cross-coupling reactions in PR&D
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Managing nitrosamines in the pharmaceutical industry: A comprehensive approach
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Optimizing solid-state properties and enhancing API bioavailability through physicochemical prediction
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Stable isotope-labeled compounds
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Unlocking the potential of high-throughput screening: Symegold library design and expansion insights
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Insights into drug discovery and development 2025
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Interview with the computer-aided drug design (CADD) department
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Meet the Organix Director, Mario Gonzalez
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Interview with the new Managing Director of Symeres Groningen
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An interview with Yadan Chen and Paul O’Shea
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An interview with Anu Mahadevan and Paul Blundell
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Crystalline and liquid crystalline 25-hydroxy-cholest-5-en-3-sulfate sodium and methods for preparing same
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In vivo pharmacokinetic experiments in preclinical drug development
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Accelerating medicinal chemistry by rapid analoging
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Solid-state chemistry part II: Optimal form selection by controlled crystallization
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Route scouting for kilogram-scale manufacturing of APIs
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Solid-state chemistry part I: Introduction
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Let us support the discovery and development of your next breakthrough.