Symeres has a strong track record in the validation and expansion of hits derived from different screening platforms, including high-throughput screens (HTS), fragment screens, DNA-encoded libraries, and AI-based virtual screens.
A cornerstone of our hit-finding activities is our 75,000 compound Symegold library, created as part of the European Lead Factory (ELF) IMI-2 consortium. The compounds in this collection were based on diverse lead-like properties and structural novelty.
The Symegold library can be accessed at the Axxam screening centers and screened alongside a series of other high-quality libraries assembled and curated by Axxam.
We have significant expertise in validating and prioritizing HTS hits, taking into account principles of lead-likeness, synthetic feasibility, IP, and ADME properties. Our parallel chemistry platform can play a decisive role in rapid hit expansion, developing both structure–activity and structure–property relationships for hit series. This, coupled with a comprehensive ADME-Tox platform, allows project teams to make informed decisions based on a solid data package.
A Smarter Starting Point for Hit Discovery
SymeGold is more than a compound count, it’s a curated library of 78,000 structurally distinctive, medicinally relevant compounds designed to fuel high-quality hit discovery.
With spirocyclic scaffolds, macrocyclic subsets (SymeCycle), and pseudo-natural products, plus rapid follow-up options and strategic screening through our partner Axxam, SymeGold helps you move from hit to lead with clarity and confidence.
