Advanced polymers in drug delivery

We design, synthesize, and analyze advanced polymers for drug delivery and conjugation applications. Our chemistry teams develop polymer-based drug delivery systems with defined molecular weight range, solubility, and release characteristics, supported by high-precision purification and analytical expertise.

As a CRO drug delivery partner, we help clients advance complex formulations and meet regulatory expectations with confidence.

Capabilities include:

  • Polymer nanoparticles (PMPs) – Design, synthesis and scale-up (including GMP) of polymers for RNA, mRNA and DNA delivery for precise targeting, enhanced stability and improved delivery performance
  • Polymer-drug conjugation – Custom linkers designed to enhance solubility, extend stability, and enable targeted release – supporting safer, more effective drug delivery and controlled therapeutic outcomes.
  • Material science polymers – Specialty and surface-functionalized polymers developed for medical and dental devices, engineered through RAFT-CT techniques enable desired characteristics (Mw, Mn, Mp, Mz and PDI) to fit your exact performance, stability, and application-specific characteristics.
  • Analytical and purification expertise – Tangential flow filtration chromatography (TFF), gel permeation chromatography (GPC), size exclusion chromatography (SEC) and advanced preparative techniques ensure polymers meet exact specifications to deliver consistent and reproducible quality.

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Lipids

Polymer chemistry expertise

15+ years of expertise

Well established in advancing polymer chemistry for drug delivery and material science applications.

Flexible delivery

Rapid and flexible synthesis turnaround and courier delivery for your urgent polymer drug delivery needs.

Integrated polymer capabilities

Advanced polymerization, analytics and scale-up under one roof with seamless IND-enabling support.

Polymer and lipid expertise in drug delivery

Our polymer programs connect directly with our lipid chemistry capabilities to create delivery materials tailored for nucleic acid and small-molecule therapeutics.

By combining expertise in custom and catalog lipids – including helper lipids, PEGs, PEG replacements, and GalNAc conjugates – we optimize formulation performance, improve stability, and accelerate the transition from discovery to clinical development.

What do our partners say?

“The team is making short work of these targets, so we will have to start thinking of some additional targets!”

Director

Biotech

“A sign that things are going well - we keep coming to you. We’ve given Symeres five or six different projects already. That’s almost unheard of for us.“

Senior Director, Manufacturing

Top 10 global pharma

“They’ve always met or exceeded my expectations - that’s why I continue to come back, company after company, year after year.”

Allen Horhota, Vice-President Platform & Delivery

Seamless Therapeutics

“If the compound can be made, Symeres will undoubtedly find out a good way to make it.”

Dooyoung Jung, CEO

Pinotbio

“Through our dedicated FTE resource at Symeres we have achieved remarkable results, not only by developing a new “aspirational” synthetic route but also by significantly improving the current one to deliver a sustainable route for commercial production and giving us two options for late development.”

Associate Director

Large pharma, Europe

“We are developing the most complex molecule that is built at this time in the world…We work with a lot of CROs, also chemistry CROs, and so far Symeres has done the best job with respect to transparency and also to troubleshoot the problems and find a solution. Over the years we have been really impressed with the work ​that Symeres has done.”

Founder

Biotech

“We’ve been with them…over 10 years. The cost, the flexibility - the value is just so strong. That’s why we’ve stuck with them.”

Senior Director, CMC

Biotech

“The progression was really phenomenal. I am truly impressed. There is a world of difference between you and other CROs.”

Start-up Founder

Biotech

“I would like to extend my thanks for the excellent work Symeres has done in synthesizing the API for Part 1 of our project. Your communication throughout the process was outstanding, and the sense of urgency with which you operated allowed us to complete this phase promptly and efficiently.”

Leader

Large biotech

Your discovery and development partner

We support programs from target exploration through IND, combining assay biology, ADME-tox, medicinal chemistry, and CMC development.

With laboratories in Europe and North America, projects remain closely supported across all phases of drug discovery and development

Resources we think you'll love

CDMO red flags you can’t ignore: Regulatory shortfalls and misalignment

Part 3: Could Regulatory Misalignment Be Delaying Your Submission? A CDMO can have the best scientists, excellent facilities, and strong technical execution, yet still fall short when it comes to regulatory alignment. This disconnect between scientific performance and regulatory readiness is one of the most damaging red flags in drug development as it could delay […]
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Whitepaper

5 CDMO red flags you can’t ignore: A guide for biotechs and pharma

Selecting the right CDMO is one of the most important choices a biotech or pharma team will make. The right partner helps you move efficiently toward IND or IMPD, safeguard quality, and anticipate regulatory needs before they become roadblocks. The wrong one can mean delays, rising costs, and lost momentum. At Exemplify BioPharma, a Symeres company, […]
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Whitepaper

CDMO red flags you can’t ignore: Underestimating technology transfer complexity

Part 2: Why “Scale-Up” Isn’t Just a Bigger Batch Transitioning a process from discovery scale to GMP manufacturing is almost never straightforward. What runs smoothly at 100 milligrams in the lab can behave very differently at the kilogram scale. Yet too many programs falter because the complexity of this transition is underestimated or treated as […]
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Blog

O.N.E Symeres: A practical approach to real-world drug development

No drug development program runs perfectly. Chemistry misbehaves, funding shifts, and timelines tighten. But what defines a reliable partner is how they respond. O.N.E Symeres is the framework we use to keep projects moving through uncertainty: openness, nimbleness, and expertise.
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Whitepaper

CDMO red flags you can’t ignore: Undefined or shifting project scope

Part 1: Is an Undefined Scope Putting Your Project at Risk? Selecting the right CDMO is one of the most important decisions in drug development. Yet even experienced biotechs and pharma companies can find themselves trapped in projects where the initial excitement gives way to frustration, and one of the most common culprits is a […]
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Whitepaper

Accelerating chemical innovation: Unveiling Symeres’ parallel chemistry

By combining automation, data-driven design, and deep synthetic expertise, Symeres is redefining how chemists generate and optimize compound libraries, bringing speed, scalability, and creativity to modern drug discovery.
View article

Webinar | On-demand

From racemic to pure the art and science of enantiomer separation

From the classical and Dutch resolution methods to preferential crystallization and deracemization, learn the best ways to obtain your desired purity!
View article

Whitepaper

IND & IMPD enabling developability roadmap

Drug discovery and development is a complex and iterative process that involves the identification, design, development, testing, and approval of new pharmaceutical drugs for use in patients. It encompasses a series of scientific, regulatory, and commercial activities aimed at discovering and bringing safe and effective medicines to the market. A key milestone in this process […]
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Whitepaper

Innovations in unnatural amino acids: Advancing functional diversity and applications

Unnatural amino acids enable groundbreaking advancements in drug discovery, biomaterials, and peptide design by introducing novel chemical functionalities that enhance stability, specificity, and bioactivity. This whitepaper highlights Symeres’ expertise in synthesizing unnatural amino acids, including side-chain modifications, N-functionalization, and cyclic variants, for applications in pharmaceuticals, diagnostics, and materials science. Utilizing advanced techniques like biocatalysis and […]
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Whitepaper

Leveraging copper-catalyzed ullmann-type cross-coupling reactions in PR&D

Our experience in overcoming scaleup challenges and harnessing the benefits of non-noble-metal catalysis makes Symeres the CRO of choice for challenging steps, such as the Ullmann reaction.
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Whitepaper

Managing nitrosamines in the pharmaceutical industry: A comprehensive approach

A comprehensive overview of nitrosamine risk assessment, including potential formation, scavenging, and analysis, is described here.
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Whitepaper

Optimizing solid-state properties and enhancing API bioavailability through physicochemical prediction

Here at Symeres, we have our new ‘Solid-State Center of Excellence’, and in this whitepaper we describe how we utilize our expertise and novel innovation to further our solid-state capabilities.
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Whitepaper

Stable isotope-labeled compounds

Discover how Symeres applies advanced synthetic chemistry and ADME expertise to design, produce, and study stable isotope-labelled compounds that enhance precision in drug development.
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Whitepaper

Unlocking the potential of high-throughput screening: Symegold library design and expansion insights

Learn how Symeres combines advanced chemistry platforms and deep discovery expertise to design and expand the SymeGold library, driving more efficient high-throughput screening and smarter hit identification.
View article

Interviews

Insights into drug discovery and development 2025

Here we interview our Director of Medicinal Chemistry, Anita Wegert, for her insights into drug discovery and development for 2025. This interview was conducted an interviewer from the Drug Discovery and Development Europe event and we were able to share our expertise. Curious how our insights can help your next project?
View article

Interviews

Interview with the computer-aided drug design (CADD) department

Our Computer Aided Drug Design department supports our clients' drug discovery projects with some of the best (predictive) software.
View article

Interviews

Meet the Organix Director, Mario Gonzalez

We are pleased to share a conversation with Dr. Mario Gonzalez, a Director at Organix, as he reflects on his journey from Argentina to Massachusetts and provides valuable career insights in celebration of his 30 years with the company.
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Interviews

Interview with the new Managing Director of Symeres Groningen

On October 2, Dr Melloney Dröge started in her new role as Managing Director for the Groningen site.
View article

Interviews

An interview with Yadan Chen and Paul O’Shea

We are pleased to introduce the founders of Symeres’ daughter company Exemplify in New Jersey: Yadan Chen, CEO, and Paul O’Shea, Chief Scientific Officer. Who are they? What do they stand for? And how does Exemplify fit with Symeres?
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Interviews

An interview with Anu Mahadevan and Paul Blundell

We proudly introduce the founders of Symeres’ daughter company Organix in Boston: Anu Mahadevan, CEO, and Paul Blundell, President at Organix. Who are they? What do they stand for? And how does Organix fit with Symeres?
View article

Blog

Crystalline and liquid crystalline 25-hydroxy-cholest-5-en-3-sulfate sodium and methods for preparing same

Organix, a Symeres company, developed scale up conditions of the synthesis of 25-hydroxy cholesterol 3-monosulfate (sodium salt) from cholesterol. After the protection of the hydroxy group (acetate) and double bond (debromination), the hydroxy group in position 25 was introduced using oxone and trifluoromethylethylketone. Then the 3-hydroxy group and double bond were deprotected, and the resulting […]
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Webinar | On-demand

In vivo pharmacokinetic experiments in preclinical drug development

Despite a good part of ADME research in drug discovery and preclinical development can be performed using various in silico or in vitro systems, eventually it becomes necessary to evaluate the pharmacokinetic (PK) profile in animals to elucidate in vivo DMPK properties of the drug candidates.
View article

Webinar | On-demand

Accelerating medicinal chemistry by rapid analoging

Medicinal chemistry is the art of rapidly evolving initial hits to clinical candidates via smart, information driven multiparametric optimization.
View article

Webinar | On-demand

Solid-state chemistry part II: Optimal form selection by controlled crystallization

The webinar by Dr. Edwin Aret of Symeres focuses on advanced strategies for selecting and controlling solid forms of pharmaceutical compounds through crystallization techniques.
View article

Webinar | On-demand

Route scouting for kilogram-scale manufacturing of APIs

The webinar by Dr. Martin Strack provides an in-depth exploration of the strategies and considerations involved in developing scalable synthetic routes for Active Pharmaceutical Ingredients (APIs)
View article

Webinar | On-demand

Solid-state chemistry part I: Introduction

This webinar, presented by solid-state expert Edwin Aret, offers an insightful introduction to the field of solid-state chemistry.
View article

Connect with our polymer drug delivery experts

See how we can support the discovery and development of your next breakthrough.