Understanding how a compound crosses biological barriers and interacts with transport proteins is essential for predicting absorption, distribution, and potential drug–drug interactions.
At Symeres, we offer a range of permeability and transporter assays that generate reliable data early in development, helping you de-risk your project, meet regulatory expectations, and make informed decisions that accelerate progress toward the clinic.
Service List
PAMPA (Parallel Artificial Membrane Permeability Assay)
Screen compounds rapidly for passive diffusion using our PAMPA platform. This high-throughput assay models transcellular permeation across a lipid-infused artificial membrane.
Caco-2/MDCK Permeability
Evaluate intestinal absorption and barrier penetration with Caco-2 and MDCK assays. These models capture both passive and active transport processes and support BCS classification.
Efflux Transporters
Assess the role of key efflux transporters such as P-gp, BCRP, and BSEP. Our substrate and inhibition assays meet EMA/FDA guidelines to identify transporter-mediated drug–drug interactions.
Uptake Transporters
Characterize drug–transporter interactions with uptake assays using human transfected cells. We provide tailored studies for SLC family transporters to predict absorption, distribution, and drug–drug interaction risks.
