Lead optimization requires fine-tuning multiple parameters. Symeres has an excellent track record of progressing programs through to candidate selection.
Clients often approach us with chemical starting points requiring lead optimization of a single or multiple parameters, such as solubility, hERG, CYP inhibition etc.
Our in-house SAR database solutions, coupled to DataWarrior and Schrödinger’s LiveDesign interfaces, allow us to effectively mine and analyze project data to efficiently design analogues and progress your lead series toward candidate selection. In many cases we integrate our parallel synthesis and purification infrastructure, generating arrays of analogs to rapidly build structure-activity and structure-property relationships, which we use to design the next generations of ligands.
