Symeres has a dedicated team focused on Rapid Analog Synthesis, enabling the swift design, synthesis, and purification of compound arrays to support early-stage hit exploration and lead optimization.
Parallel array synthesis is a powerful strategy for quickly probing the chemical space around a hit compound. At Symeres, we’ve established efficient, highly adaptable workflows that enable streamlined design, synthesis, and purification of focused libraries. Our approach leverages semi-automated platforms that balance speed with flexibility, giving our chemists the ability to tailor each library to the unique goals of your program.
Whether you’re looking to generate a small set of analogues or explore broader structure–activity relationships with hundreds of compounds, our platform can be adapted to fit your requirements. In addition to short-turnaround library generation, we also support larger and more complex synthesis efforts over extended timelines.
One such example is the creation of our proprietary Symegold library: a diverse collection of 75,000 lead-like compounds designed and synthesized by Symeres as part of the European Lead Factory initiative. This valuable screening resource is now available through our strategic partner, Axxam, providing opportunities to access novel starting points for a wide range of therapeutic areas.
