Our Solid-State Chemistry and Pre-Formulation experts can help you to selectively crystallize the optimal stable form and formulate your compound.
A controlled crystallization is the preferred isolation method to obtain purified material of a specific polymorphic (salt) form and crystal habit. The solid form determines the stability, solubility and permeability of the compound; therefore, the selection of a pharmaceutically suitable form will manage the risks in further development. The pre-formulation experts study excipient compatibility, pH-dependent solubility and dissolution rate optimization to improve the bioavailability. Symeres has performed hundreds of form characterization and selection screens on innovative APIs throughout the years.
Read more about our Solid-State capabilities.
Watch the new video of our Solid-State Center of Excellence:
Discover Exemplify
We deliver a number of services in partnership with Exemplify BioPharma, a global Partnership Research Organization (PRO) offering end-to-end CMC solutions under one roof.
Exemplify offers:
- Integrated project management across Process Chemistry, Analytical Chemistry, and Formulation Development
- Expert oversight on CRO/CMO selection, contracting, and management
- Comprehensive support with CMC regulatory submissions (IND, IMPD, NDA, MAA)
- Full Quality Assurance and compliance sign-off
- Efficient timeline and budget management
Their newly expanded Formulation Suite also opens the door to enhanced formulation capabilities, strengthening support from early development through to commercialization.
