Introduction
We provide in vitro ADME, in vivo PK, and toxicology studies as standalone services or fully integrated programs to generate clear, connected data to guide confident decisions from discovery to IND.
Physicochemistry and Binding
Physicochemical parameters give information about the “drug-likeness” of the compound, with respect to absorption from the intestine. Information about these properties is also valuable when planning optimum conditions for other in vitro ADME assays.
Permeability and Transporters
Several assays are available for evaluating permeability and identifying drug transporter substrates or inhibitors. Including PAMPA, Caco-2/MDCK permeability, Efflux transporters & Uptake transporters.
In Vitro Metabolism
High-quality in vitro metabolism services are available to evaluate the metabolic fate of the compound in liver or extrahepatic tissues. The samples are analysed with state-of-the-art UPLC/HR-MS equipment.
Drug Interactions
Evaluating drug-drug interaction risk is a crucial part of drug safety evaluation required by the drug regulatory authorities. The available services cover the identification of metabolising enzymes, enzyme inhibition and enzyme induction assays, as well as transporter-mediated drug-drug interactions.
In Vitro Toxicology
Information about in vitro toxicity early on during the drug discovery process support your internal decision making. The available non-GLP in vitro toxicology assays are planned for cost-efficient screening with low compound consumption and cover the most commonly faced toxicity related challenges.
In Vivo Drug Metabolism and Pharmacokinetics
The in vivo DMPK services cover a variety of animal experiments in several species. In-house rodent PK studies are carried out in AAALAC accredited animal facilities and studies with other species are completed together with selected European in-life partners.
Safety Metabolism and In Vivo MetID
Safety metabolism studies help you to confirm that the exposure to human metabolites is adequate in preclinical safety species, or to effectively identify potential MIST (metabolites in safety testing) issues in time, through a battery of different types of in vivo MetID studies.
Your transatlantic drug development partner
We integrate ADME-tox and DMPK expertise into broader drug discovery and development programs with openness, agility and scientific depth. Our connected teams in Europe and North America share data transparently, adapt quickly to new results, and stay accountable from first experiments to IND, to keep your progress clear, connected and continuous.
Integrated technologies for smarter drug development
Our ADME-tox services are linked with medicinal chemistry, in vitro pharmacology, process development, solid-state chemistry and CMC. This ensures consistent data flow from lead optimization to regulatory studies and early GMP supply. This integration supports clear decisions and helps you progress your small-molecule programs faster.
