Our in vivo drug metabolism and DMPK services provide comprehensive support for understanding the absorption, distribution, metabolism, and excretion of your compound across species.
We operate AAALAC-accredited in-house facilities for rodent studies and collaborate with trusted European in-life partners for work in other species, always selecting the most suitable partner based on study requirements. From study design and dosing to bioanalysis and pharmacokinetic evaluation, we manage the entire process, delivering reliable, high-quality data to guide your development decisions.
Service List
Animal Pharmacokinetics
Design and execute tailored PK studies in rodents within our AAALAC-accredited facilities, or with partner sites for other species. We offer single and repeat dosing, cassette dosing, and multiple administration routes (i.v., p.o., s.c., i.m., i.p.), with full bioanalysis and PK evaluation to deliver clear insights into compound disposition.
In vivo Metabolite Identification (MetID)
Identify and profile circulating or excreted metabolites directly from in vivo studies. Using LC-MS/MS, UPLC-HR/MS, and radiodetection, we characterize metabolite structures, quantify exposure, and assess pharmacokinetics relative to the parent drug across species.
