Optimizing Solid-State Properties and Enhancing API Bioavailability through Physicochemical Prediction

Solid-state chemistry research is a key part of the evaluation of whether a molecule is a “druggable” compound, by selecting the optimal form based on physicochemical and biopharmaceutical properties and manufacturability. To be suitable as a medicine, the candidate molecule should show sufficient solubility, dissolution, and bioavailability, as well as good stability – both chemical and physical. These properties will lead to a developability program, to minimize the timelines and manage risks. Here at Symeres, we have our new ‘Solid-State Center of Excellence’, and in this white paper we describe how we utilize our expertise and novel innovation to further our solid-state capabilities.