Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II

In 2016, Stefan Krauss and Jo Waaler (University Hospital of Oslo, Norway) approached Symeres to optimize their lead OD-336 as a tankyrase inhibitor. All compounds that were created for this project are covered by three patents, and in 2020 we published a paper in J. Med. Chem. We now have a follow-on paper being published, and a third biology paper is close to submission to a publisher.

 
 

Development Centres of Excellence Network Lead Optimization Hit Generation Lead Optimization
 
 
 
 
 

Development Centres of Excellence Network Lead Optimization Hit Generation Lead Optimization
 
 
 
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