Large-Scale Cyclopropanation of Butyl Acrylate with Difluorocarbene and Classical Resolution of a Key Fluorinated Building Block

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Pharmacokinetic Modeling of [11C]GSK-189254, PET Tracer Targeting H3 Receptors, in Rat Brain

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Mol. Pharmaceutics 2022, 19, 3, 918–928
Year
2022
Customer
UMCG
Symeres authors
Maria Kominia, Martin Koelewijn
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α-C-H photoalkylation of a glucose derivative in continuous flow

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Year
2022
Customer
UMC Gronignen
Symeres authors
Marc Mouthaan, Mark Borst, Kees Pouwer
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A New Class of Tunable Acid-Sensitive Linkers for Native Drug Release Based on the Trityl Protecting Group

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Bioconjugate Chem. 2022, XXXX, XXX, XXX-XXX
Year
2022
Customer
Cristal Therapeutics
Symeres authors
Roel Bell, Peter Lenting
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TMTHSI, a superior 7-membered ring alkyne containing reagent for strain-promoted azide–alkyne cycloaddition reactions

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Chemical Science 2022, 33
Year
2022
Customer
Cristal Therapeutics
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Harald Veldhuis, Tommi Meulemans
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Discovery of 2,4-1H-Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors

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ACS Medicinal Chemsitry Letters, coming soon
Year
2021
Customer
X-Chem, Inc.
Symeres authors
Johan Veerman, Yorik Bruseker, Eddy Damen, Erik Heijne, Wendy van Brugge, Koen Hekking, Rob Winkel, Peter van Rijnsbergen
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Counteracting Enantiospecific Behavior of Tailor-Made Additives During Chiral Symmetry Breaking: Growth Inhibition versus Solid-Solution Formation

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Isr. J. Chem. 2021, 61, 1 – 6
Year
2021
Customer
Ardena
Symeres authors
Michel Leeman, Richard Kellogg
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Resolution of a Metastable Racemic Compound of Anhydrous Phencyphos by Hydrate Formation

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Crystals 2021 (11), 1225
Year
2021
Customer
Symeres
Symeres authors
Michel Leeman and Richard M. Kellogg
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Exploration of a Nitromethane-Carbonylation Strategy during Route Design of an Atropisomeric KRASG12C Inhibitor

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J. Org. Chem. 2021
Year
2021
Customer
AstraZeneca
Symeres authors
Cati Ferrer
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A new approach to produce [18F]MC225 via one-step synthesis, a PET radiotracer for measuring P-gp function

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Khaled Attia, John Carlo Sembrano, Olivier Jacquet, Ton Visser
Year
2021
Customer
UMCG
Symeres authors
Garcia-Varela et al. EJNMMI Radiopharmacy and Chemistry (2021) 6:24
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GMP Compliant Synthesis of [18F]Canagliflozin, a Novel PET Tracer for the Sodium−Glucose Cotransporter 2

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J. Med. Chem. (2021), 64, 22, 16641–16649
Year
2021
Customer
UMCG
Symeres authors
Olivier Jacquet, Ton Visser, Andre Heeres, Khaled Attia
 
 

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Development Centres of Excellence Network Lead Optimization Hit Generation Lead Optimization
 
 
 
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