Methylation of geometrically constrained lysine analogues by histone lysine methyltransferases

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Pre-clinical lead optimization of a 1,2,4-triazole based tankyrase inhibitor

Publication
J. Med. Chem., 2020, xxxx
Year
2020
Customer
Oslo University
Symeres authors
Ruben Leenders, Piotr Nieczypor, Sjoerd Aertsen, Eddy Damen, Anita Wegert
Publication

Open Innovation and Pharma R&D Transformation: New Opportunities for Academic Research Institutions, Contract Research Organizations, and Biotech Companies

Publication
MEDCHEM NEWS Vol.30 No.1
Year
2020
Customer
MercachemSyncom
Symeres authors
Luc van Hijfte, Norimasa Morita, Bart DeCorte, Marleen Dolman
Publication

Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor

Publication
J. Med. Chem. 2020, 63, 6834-6846
Year
2020
Customer
Oslo University
Symeres authors
Ruben Leenders, Piotr Nieczypor, Sjoerd Aertsen, Eddy Damen, Anita Wegert
Publication

The synthesis of 13C6-labeled l-thyronine, 3,5-diiodothyronine, 3,3′,5-triiodothyroacetic acid and 3,3′,5,5′-tetraiodothyroacetic acid

Publication
Tetrahedron 2020 (76), 33, 131352
Year
2020
Customer
Erasmus MC
Symeres authors
Gregor Pilzak, Toine van den Bergh, Tommi Meulemans
Publication

Performance Analysis and Model-Free Design of Deracemization via Temperature Cycles

Publication
Org. Process Res. Dev. 2020
Year
2020
Customer
ETH institute
Symeres authors
Michel Leeman, Richard Kellogg
Publication

Enantiospecific Solid Solution Formation Triggers the Propagation of Homochirality

Publication
Angew. Chem. Int. Ed. 2020, 59, 1 – 6
Year
2020
Customer
AMOLF
Symeres authors
Michel Leeman, Richard Kellogg
Publication

Scalable Synthesis of 17S-FD-895 Expands the Structural Understanding of Splice Modulatory Activity

Publication
Cell Reports Physical Science 2020 (1), 12, 100277
Year
2020
Customer
UCSD
Symeres authors
Mark Verhaar, Martijn Slagt, Dominika Bachera, Minze Rispens, Remco Hofman, Vincent de Boer, Rory van der Hulst Rutger Bus, Pieter Hiemstra
Publication

Modular Medical Imaging Agents Based on Azide–Alkyne Huisgen Cycloadditions: Synthesis and Pre-Clinical Evaluation of 18F-Labeled PSMA-Tracers for Prostate Cancer Imaging

Publication
Chemistry A European Journal 27, 23, 6993
Year
2020
Customer
Dutch Provinces Overijssel and Gelderland
Symeres authors
Marten Klopstra, Ton Visser, Keimpe-Oeds van den Berg
Publication

Practical Synthesis of a Stable Precursor for Positron Emission Tomography Imaging Agent 18F-GTP1 (Exemplify)

Publication
Org. Process Res. Dev. 2020, 24, 9, 1690–1699
Year
2020
Customer
Genentech
Symeres authors
William Nack, Paul O'Shea
Publication

Bivalent Ligands for Protein Degradation in Drug Discovery

Publication
Comp. and Struc. Biotech. J., (17), 2019, 160-176
Year
2019
Customer
MercachemSyncom
Symeres authors
Marcel Scheepstra, Koen Hekking, Luc van Hijfte, Rutger Folmer
 
 

Development Centres of Excellence Network Lead Optimization Hit Generation Lead Optimization
 
 
 
 
 

Development Centres of Excellence Network Lead Optimization Hit Generation Lead Optimization
 
 
 
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