Methylation of geometrically constrained lysine analogues by histone lysine methyltransferases

Publication

Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation

Publication
Drug Design, Development and Therapy 2019, 13, 345-364
Year
2019
Customer
VU UMC, UMCG, Chaperone Pharma
Symeres authors
Jean-Paul Seerden, Lizette Loen, Andre Heeres
Publication

Stable pantothenamide bioisosteres: novel antibiotics for Gram-positive bacteria

Publication
J. Antibiotics (2019), 72, 682-692
Year
2019
Customer
Chiralix
Symeres authors
Richard Blaauw
Publication

Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum

Publication
Sci. Transl. Med. (2019), 11(510), eaas9917
Year
2019
Customer
Chiralix
Symeres authors
Richard Blaauw
Publication

Structure–Activity Relationship Studies on (R)-PFI-2 Analogues as Inhibitors of Histone Lysine Methyltransferase SETD7

Publication
ChemMedChem, 2018, 13, 1405 – 1413
Year
2018
Customer
Institute for Molecules and Materials
Symeres authors
Eddy Damen, Ruben Leenders, Richard Blaauw
Publication

Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity

Publication
Journal of Medicinal Chemistry, 2018, 61, (9), 3870-3888
Year
2018
Customer
TI Pharma
Symeres authors
Johan Veerman, Toine van de Bergh
Publication

Microwave-assisted diastereoselective two-step three-component synthesis for rapid access to drug-like libraries of substituted 3-amino-β-lactams

Publication
Bioorg. Med. Chem. 2018, 26, 41-49
Year
2018
Customer
Leiden University Medical Center
Symeres authors
Joyce van den Heuvel, Rik Megens, Jorg Benningshof
Publication

The Strecker reaction coupled to Viedma ripening: a simple route to highly hindered enantiomerically pure amino acids

Publication
Chem. Comm., 2018, 54, 10832-10834
Year
2018
Customer
AMOLF
Symeres authors
Michel Leeman, Richard Kellogg
Publication

Synthesis of yellow fluorescent dyes derived from benzoxanthene that can be used in colour converters for remote phosphor LED systems

Publication
Dyes and pigments, 2018, 149, 662-668
Year
2018
Customer
Philips
Symeres authors
Sylvain Hamon, Ton Visser
Publication

Drug-target residence time: A misleading concept

Publication
Drug Discovery 23, 1, (2018,) 12-16
Year
2018
Customer
Symeres authors
Rutger folmer
Publication

A multi-gram-scale stereoselective synthesis of Z-endoxifen

Publication
Bioorg. Med. Chem. Lett 28 (2018) 1352–1356
Year
2018
Customer
TU eindhoven
Symeres authors
Bartjan Koning, Jan Koek
 
 

Development Centres of Excellence Network Lead Optimization Hit Generation Lead Optimization
 
 
 
 
 

Development Centres of Excellence Network Lead Optimization Hit Generation Lead Optimization
 
 
 
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