Stability in Plasma, Buffer or Biorelevant Media

  • Identification of degradation products

Stability of new chemical entities in gastric or intestinal fluid may in some cases be a limiting factor of bioavailability, already before the actual absorption across intestinal membranes to blood circulation. Similarly, low plasma stability may cause low levels in circulation, and may affect also to the results from quantitative plasma analysis, if the compound is unstable between sample collection and analytical step. Therefore, the identification of these processes, both qualitatively and quantitatively, is highly important.

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