Rapid deracemization through solvent cycling: proof-of-concept using a racemizable conglomerate clopidogrel precursor

Posted on 18 September 2023

In collaboration with the AMOLF institute, we demonstrate that a conglomerate-forming clopidogrel precursor undergoing solution phase racemization can be deracemized through cyclic solvent removal and re-addition in this Chemical Communications article. We establish that the combination of slow growth and fast dissolution of crystals is ideal for rapid deracemization, which we achieve by repurposing a Soxhlet apparatus to realize the slow removal and fast re-addition of solvent autonomously. To learn more about Symeres’ chiral technologies and how these can help your projects, click here.

Rapid deracemization process Symeres

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