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Drug Discovery

From hit finding to clinical candidate identification

Symeres offers best-in-class chemistry solutions for drug discovery and early drug development. Our discovery services span from early stage hit finding to clinical candidate identification.


Our Drug Discovery Services

Hit Generation and Hit to lead activities

Symeres has a strong track record in the validation of hits derived from different screening platforms. Our parallel chemistry capabilities allow us to make many analogs rapidly and cost-effectively.

Lead Optimization

Lead optimization requires multi-parametric fine-tuning. Using our in-house SAR database we efficiently design analogues to progress your lead series toward clinical candidate selection.

Computational Chemistry

From bioisosteric replacements to interactive structure and ligand-based drug design, computational chemistry is an integral part of many of our medicinal chemistry projects. At Symeres we develop modeling approaches tailored to customer requirements.

Rapid Analog Synthesis

High throughput is essential to rapidly explore the chemical space around a hit compound. Symeres has a dedicated team for the design and synthesis of compound arrays, with a focus on novel, 3D scaffolds.

Integrated Drug Discovery

Together with our network of centers of excellence, Symeres can provide integrated drug discovery for our clients.

PROTACs

Proteolysis targeting chimeras (PROTACs) are considered a promising new modality for therapeutic intervention. We have developed a modular chemistry toolbox, in which different linking strategies are combined with optimized analytical routines.

ADME

We now have a number of in vitro ADME assays available to support your multi-parameter medicinal chemistry optimization even further.

Hit Generation and Hit to lead activities

Symeres has a strong track record in the validation of hits derived from different screening platforms. Our parallel chemistry capabilities allow us to make many analogs rapidly and cost-effectively.

Lead Optimization

Lead optimization requires multi-parametric fine-tuning. Using our in-house SAR database we efficiently design analogues to progress your lead series toward clinical candidate selection.

Computational Chemistry

From bioisosteric replacements to interactive structure and ligand-based drug design, computational chemistry is an integral part of many of our medicinal chemistry projects. At Symeres we develop modeling approaches tailored to customer requirements.

Rapid Analog Synthesis

High throughput is essential to rapidly explore the chemical space around a hit compound. Symeres has a dedicated team for the design and synthesis of compound arrays, with a focus on novel, 3D scaffolds.

Integrated Drug Discovery

Together with our network of centers of excellence, Symeres can provide integrated drug discovery for our clients.

PROTACs

Proteolysis targeting chimeras (PROTACs) are considered a promising new modality for therapeutic intervention. We have developed a modular chemistry toolbox, in which different linking strategies are combined with optimized analytical routines.

ADME

We now have a number of in vitro ADME assays available to support your multi-parameter medicinal chemistry optimization even further.

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