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Official opening of new Oncolines home, the Marie Curie Building at the Pivot Park in Oss, The Netherlands
After months of dedication and collaboration, the official opening of the Marie Curie building at the Pivot Park in Oss was opened on Sep 19th, 2024. The Marie Curie building is a multitenant laboratory building which houses Oncolines B.V., the in vitro biology services laboratory of Symeres. Read more about this exciting development!
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J. Med. Chem. Publication: Preclinical Lead Optimization of a 1,2,4-Triazole-Based Tankyrase Inhibitor
In collaboration with Oslo University Hospital, we report the synthesis and biological activity of novel 1,2,3-triazole-based tankyrase inhibitors. Through a modular synthetic pathway and X-ray crystallography supported SAR analysis, we synthesized a series of novel TNKS inhibitors with improved ADME profiles, exhibiting antiproliferative efficacy in colorectal cancer cell lines. Click on the link below for a short summary of this publication.
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New video of our Solid-State Center of Excellence
In this new video our colleagues Gabriella Pizutti, Chantalle van Berkel, and Eva Verhofstad, will give you an exciting lab tour through the Symeres Solid-State Centre of Excellence, located at the Symeres site in Weert, the Netherlands. You will learn more about PhysChem Properties, Solid Form Screening, Crystallization, Crystal Habit, Pre-formulation, and Formulation. Feel free to contact us via the contact form on this website if you would like to learn more about our Solid-State capabilities.
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Marina Virgili about Barcelona and Groningen
We had the pleasure of sitting down with Marina Virgili, a dynamic and accomplished professional with a fascinating history in the pharmaceutical industry. Originally from the beautiful city of Barcelona, Marina shared insights into her background, career, and the unique experiences she has encountered along the way.
Latest patents
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Compounds and their use as PDE4 activators
Number: WO/2024/038129
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Compounds and their use as PDE4 activators
Number: WO/2024/038128
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Crystalline and liquid crystalline 25-hydroxy-cholest-5-en-3-sulfate sodium and methods for preparing same (Organix)
Number: US 2023/0056273 A1
Latest publications
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Rare Case of Polymorphism in the Binary System of Enantiomers of a Praziquantel Derivative
Article: Org. Process Res. Dev. 2024, 28, 4, 1224–1232
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Towards Multitargeted Ligands as Pain Therapeutics: Dual Ligands of the Cavα2δ-1 Subunit of Voltage-Gated Calcium Channel and the μ-Opioid Receptor
Article: ChemMedChem 2024, e202300473
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High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of Plasmodium falciparum
Article: ACS Infect. Dis. 2024, XXXX, XXX, XXX-XXX
Feel free to contact us!
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